| TAZ-TFG-2024-2220 |
Dermatitis atópica canina: Respuesta al tratamiento con oclacitinib y/o lokivetmab en función del fenotipo clínico y la raza.
Guyon, Maya
Maria Teresa Verde Arribas (dir.)
Universidad de Zaragoza,
VET,
2024
Patología Animal department, Medicina y Cirugía Animal area
Graduado en Veterinaria
Tipo de Trabajo Académico: Trabajo Fin de Grado
Notas: Atopic dermatitis is a chronic skin syndrome: the close relationship between genetic, environmental and immune factors conditions the integrity of the skin barrier in patients. The treatment of atopic dermatitis is complex in both humans and dogs. The following development will be based on the current scientific literature to support the hypothesis of the possible existence of a racial predisposition in the response to treatment with oclacitinib and lokivetmab and would be an interesting topic to develop in studies of larger numbers of patients. In the first part, the pathogenesis of atopic dermatitis will be recalled and the mechanisms of action of the two drugs studied will be explained. In the following part, the main differences with human atopic dermatitis and the different existing treatments in human medicine will be studied, in order to know if there are different treatments according to the type of skin affected (i.e. according to the ethnicity to which the patient belongs). Finally, a statistical study will be carried out with patients from the Dermatology Service of the Veterinary Hospital of the University of Zaragoza (Dermatology-HCV-UNIZAR) treated with oclacitinib and/or lokivetmab, in five different breeds of dogs (Shih Tzu, Water dog, Bichon, French Bulldog, Yorkshire Terrier), to see if the variability in the results obtained with each treatment and the breed of dog can be correlated.
Notas: Atopic dermatitis is a chronic skin syndrome: the close relationship between genetic, environmental and immune factors conditions the integrity of the skin barrier in patients. The treatment of atopic dermatitis is complex in both humans and dogs. The following development will be based on the current scientific literature to support the hypothesis of the possible existence of a racial predisposition in the response to treatment with oclacitinib and lokivetmab and would be an interesting topic to develop in studies of larger numbers of patients. In the first part, the pathogenesis of atopic dermatitis will be recalled and the mechanisms of action of the two drugs studied will be explained. In the following part, the main differences with human atopic dermatitis and the different existing treatments in human medicine will be studied, in order to know if there are different treatments according to the type of skin affected (i.e. according to the ethnicity to which the patient belongs). Finally, a statistical study will be carried out with patients from the Dermatology Service of the Veterinary Hospital of the University of Zaragoza (Dermatology-HCV-UNIZAR) treated with oclacitinib and/or lokivetmab, in five different breeds of dogs (Shih Tzu, Water dog, Bichon, French Bulldog, Yorkshire Terrier), to see if the variability in the results obtained with each treatment and the breed of dog can be correlated.
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trabajos-academicos-universidad-zaragoza > centro > facultad-de-veterinaria
trabajos-academicos-universidad-zaragoza > trabajos-fin-grado