000152986 001__ 152986
000152986 005__ 20251017144552.0
000152986 0247_ $$2doi$$a10.3389/fnbeh.2019.00278
000152986 0248_ $$2sideral$$a116397
000152986 037__ $$aART-2020-116397
000152986 041__ $$aeng
000152986 100__ $$aCalpe-Lopez, Claudia
000152986 245__ $$aBehavioral Traits Associated With Resilience to the Effects of Repeated Social Defeat on Cocaine-Induced Conditioned Place Preference in Mice
000152986 260__ $$c2020
000152986 5060_ $$aAccess copy available to the general public$$fUnrestricted
000152986 5203_ $$aThe relationship between stress and drug use is well demonstrated. Stress-induced by repeated social defeat (RSD) enhances the conditioned place preference (CPP) induced by cocaine in mice. The phenomenon of resilience understood as the ability of subjects to overcome the negative effects of stress is the focus of increasing interest. Our aim is to characterize the behavior of resilient animals with respect to the effects of RSD on the CPP induced by cocaine. To this end, 25 male C57BL/6 mice were exposed to stress by RSD during late adolescence, while other 15 male mice did not undergo stress (controls). On the 2 days following the last defeat, all the animals carried out the elevated plus maze (EPM) and Hole Board, Social Interaction, Tail Suspension and Splash tests. Three weeks later, all the animals performed the CPP paradigm with a low dose of cocaine (1 mg/kg). Exposure to RSD decreased all measurements related to the open arms of the EPM. It also reduced social interaction, immobility in the tail suspension test (TST) and grooming in the splash test. RSD exposure also increased the sensitivity of the mice to the rewarding effects of cocaine, since only defeated animals acquired CPP. Several behavioral traits were related to resilience to the potentiating effect of RSD on cocaine CPP. Mice that showed less submission during defeat episodes, a lower percentage of time in the open arms of the EPM, low novelty-seeking, high social interaction, greater immobility in the TST and a higher frequency of grooming were those that were resilient to the long-term effects of social defeat on cocaine reward since they behaved like controls and did not develop CPP. These results suggest that the behavioral profile of resilient defeated mice is characterized by an active coping response during episodes of defeat, a greater concern for potential dangers, less reactivity in a situation of inevitable moderate stress and fewer depressive-like symptoms after stress. Determining the neurobehavioral substrates of resilience is the first step towards developing behavioral or pharmacological interventions that increase resilience in individuals at a high risk of suffering from stress.
000152986 536__ $$9info:eu-repo/grantAgreement/ES/MICINN/FEDER/PSI2017-83023
000152986 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttps://creativecommons.org/licenses/by/4.0/deed.es
000152986 590__ $$a3.558$$b2020
000152986 591__ $$aBEHAVIORAL SCIENCES$$b13 / 53 = 0.245$$c2020$$dQ1$$eT1
000152986 591__ $$aNEUROSCIENCES$$b144 / 273 = 0.527$$c2020$$dQ3$$eT2
000152986 592__ $$a1.26$$b2020
000152986 593__ $$aBehavioral Neuroscience$$c2020$$dQ1
000152986 593__ $$aNeuropsychology and Physiological Psychology$$c2020$$dQ1
000152986 593__ $$aCognitive Neuroscience$$c2020$$dQ1
000152986 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000152986 700__ $$aGarcia-Pardo, María Pilar$$uUniversidad de Zaragoza
000152986 700__ $$aMartínez-Caballero, María Ángeles
000152986 700__ $$aSantos-Ortiz, Alejandra
000152986 700__ $$aAguilar, María Asunción
000152986 7102_ $$14009$$2735$$aUniversidad de Zaragoza$$bDpto. Psicología y Sociología$$cÁrea Psicolog.Evolut.Educac
000152986 773__ $$g13 (2020), [20 pp.]$$pFrontiers in behavioral neuroscience$$tFRONTIERS IN BEHAVIORAL NEUROSCIENCE$$x1662-5153
000152986 8564_ $$s2409070$$uhttps://zaguan.unizar.es/record/152986/files/texto_completo.pdf$$yVersión publicada
000152986 8564_ $$s2535680$$uhttps://zaguan.unizar.es/record/152986/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000152986 909CO $$ooai:zaguan.unizar.es:152986$$particulos$$pdriver
000152986 951__ $$a2025-10-17-14:12:03
000152986 980__ $$aARTICLE