000152992 001__ 152992
000152992 005__ 20251017144555.0
000152992 0247_ $$2doi$$a10.1016/j.jad.2020.01.102
000152992 0248_ $$2sideral$$a116537
000152992 037__ $$aART-2020-116537
000152992 041__ $$aeng
000152992 100__ $$aSanada, K.
000152992 245__ $$aGut microbiota and majore depressive disorder: A systematic review and meta-analysis
000152992 260__ $$c2020
000152992 5203_ $$aBackground: Growing attention has been paid to the field of gut microbiota for mental disorders over the last decade. However, to our knowledge, no studies have conducted systematic reviews on the association between gut microbiota and major depressive disorder (MDD) in both interventional and non-interventional studies. Methods: We conducted a systematic review and meta-analysis of 16 studies (10 observational 701 participants] and six interventional trials 302 participants]) examining gut microbiota in patients with MDD. The primary outcome measures were differences in the profile of microbiota inthe observational studies, and symptom changes for depression between pre- and post-intervention with probiotics in the interventional trials. Results: In the observational studies, significant reductions in several taxa at the family and genus levels were observed in patients with MDD compared to non-depressed controls. In the interventional studies with probiotics, a significant improvement was found in depressive symptomatology compared to controls (SMD = .-1.62, 95% CI = .-2.73 to -0.51, p< 0.01). Limitations: Lack of consideration of the effects of diet and pharmacotherapy was a possible limitation. Conclusions: Our results indicate that several taxa at the family and genus levels, specifically family Prevotellaceae, genus Coprococcus, and Faecalibacterium, were decreased in MDD compared to non-depressed controls in observational studies, and depressive symptoms were improved compared to controls in interventional studies with probiotics. Due to the limited number of studies, further studies considering diet and pharmacotherapy are needed to explore the relationships between gut microbiota and MDD in humans. © 2020 Elsevier B.V.
000152992 540__ $$9info:eu-repo/semantics/closedAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/
000152992 590__ $$a4.839$$b2020
000152992 591__ $$aPSYCHIATRY$$b25 / 142 = 0.176$$c2020$$dQ1$$eT1
000152992 591__ $$aCLINICAL NEUROLOGY$$b53 / 208 = 0.255$$c2020$$dQ2$$eT1
000152992 591__ $$aPSYCHIATRY$$b40 / 155 = 0.258$$c2020$$dQ2$$eT1
000152992 592__ $$a1.891$$b2020
000152992 593__ $$aPsychiatry and Mental Health$$c2020$$dQ1
000152992 593__ $$aClinical Psychology$$c2020$$dQ1
000152992 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000152992 700__ $$aNakajima, S.
000152992 700__ $$aKurokawa, S.
000152992 700__ $$0(orcid)0000-0002-2116-9257$$aBarceló-Soler, A.
000152992 700__ $$aIkuse, D.
000152992 700__ $$aHirata, A.
000152992 700__ $$aYoshizawa, A.
000152992 700__ $$aTomizawa, Y.
000152992 700__ $$0(orcid)0000-0001-6261-3724$$aSalas-Valero, M.
000152992 700__ $$aNoda, Y.
000152992 700__ $$aMimura, M.
000152992 700__ $$aIwanami, A.
000152992 700__ $$aKishimoto, T.
000152992 773__ $$g266 (2020), 1-13$$pJ. affect. disord.$$tJournal of Affective Disorders$$x0165-0327
000152992 8564_ $$s1199706$$uhttps://zaguan.unizar.es/record/152992/files/texto_completo.pdf$$yVersión publicada
000152992 8564_ $$s2307506$$uhttps://zaguan.unizar.es/record/152992/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000152992 909CO $$ooai:zaguan.unizar.es:152992$$particulos$$pdriver
000152992 951__ $$a2025-10-17-14:12:58
000152992 980__ $$aARTICLE