153033 20251017144643.0 doi 10.1016/j.bbih.2025.100984 sideral 143507 ART-2025-143507 eng Lengvenyte, Aiste Temporal dynamics of inflammatory, platelet, and neurotrophic markers during social stress in relation to suicidal ideation and suicide attempt history 2025 Access copy available to the general public Unrestricted Interpersonal stress is a major precipitant of suicidal ideation (SI) and suicide attempts (SA), yet the underlying biological mechanisms remain unclear. This study examined dynamic plasma concentrations of inflammatory, platelet activation, and neurotrophic markers during acute social stress in 76 depressed women (mean age: 39.7 ± 1.39 years) with and without SA history or recent SI. Participants underwent the Trier Social Stress Test, with biomarkers measured at five time points before, during, and after the stressor. Covariate-adjusted growth curve models and area under the curve analyses were applied. SI was associated with elevated overall TNF-α levels (0.82 ± 0.05 vs. 0.61 ± 0.05, p = 0.039). Participants without SI showed cubic trajectories in TNF-α (t228 = 4.76, p < 0.001) and MIP-1β (t235 = 2.12, p = 0.035), and quadratic trajectories in platelet markers TSP-1 (t274 = −2.42, p = 0.016), PF-4 (t274 = −2.25, p = 0.025), and NAP-2 (t274 = −2.43, p = 0.016), which were absent in participants with SI. Cubic patters in inflammatory responses were also observed in participants without SA history, but not in suicide attempters (TNF-α: t228 = 3.15, p = 0.030; MIP-1β: t235 = 2.74, p = 0.007). Meanwhile, participants with SI or SA, but not those without, showed a linear BDNF increase (t275 = 2.39, p = 0.017; t275 = 2.28, p = 0.024, respectively). These findings suggest that SI and SA may be associated with impaired dynamic immune-inflammatory, platelet, and neurotrophic systems responses to acute interpersonal stress, reflecting systemic biological rigidity. info:eu-repo/semantics/openAccess by https://creativecommons.org/licenses/by/4.0/deed.es info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Olié, Emilie Cognasse, Fabrice Hamzeh-Cognassse, Hind Alacreu-Crespo, Adrian Universidad de Zaragoza (orcid)0000-0002-0633-2810 Courtet, Philippe 4009 680 Universidad de Zaragoza Dpto. Psicología y Sociología Área Person.Eval.Trat.Psicoló. 45 (2025), 100984 Brain, behavior, & immunity. Health 2666-3546 2077559 http://zaguan.unizar.es/record/153033/files/texto_completo.pdf Versión publicada 2472126 http://zaguan.unizar.es/record/153033/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:153033 articulos driver 2025-10-17-14:32:53 ARTICLE