153041 20251017144651.0 doi 10.3389/fbioe.2025.1504769 sideral 143453 ART-2025-143453 eng Dahaghin, Ali Biomechanical simulations of crystalline lens oscillations resulting from the changes in the gaze in an accommodated eye 2025 Access copy available to the general public Unrestricted Purpose: The goal of the study is to introduce a generic, versatile biomechanical model that aims to reproduce the dynamic wobbling phenomenon. Methods: A systematic strategy is used, which includes a) capturing the in vivo data on a group of healthy volunteers, b) analyzing the changes in Purkinje images over time, and c) performing the combined biomechanical and optical simulations to develop the model that might be useful for understanding the mechanical behavior of the lens during wobbling and its influence on ocular dynamics. Results: Examples of lens wobbling patterns for six measured eyes were presented, and parameters characterizing the oscillatory motion were determined, including frequency of oscillations, Q-factor, damping factor and time constant. The average values of these parameters are the following: frequency: 20.0 ± 2.4 Hz; Q-factor: 1.86 ± 0.44; damping factor: 0.27 ± 0.06; time constant: 0.11 ± 0.06 s. The data reproduced by means of simulations: frequency: 19.3 Hz; Q-factor: 2.17; damping factor: 0.23; time constant: 0.15 s. This comparison reveals a good agreement between the measured and reconstructed data with the values being within the standard deviation limits. Conclusion: The developed generic model together with the presented methodology is able to reconstruct the typical crystalline lens wobbling dynamics with a satisfying accuracy. However, the observed intersubject variability highlights the need for personalized biomechanical models. The introduced model may constitute the basis for future individualization of the data, bringing broad perspectives for prospective investigations aimed to explain the biomechanical mechanisms within the eye. info:eu-repo/grantAgreement/EC/H2020/956720/EU/Opto-Biomechanical Eye Research Network/OBERON This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 956720-OBERON info:eu-repo/semantics/openAccess by https://creativecommons.org/licenses/by/4.0/deed.es info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Salimibani, Milad Boszczyk, Agnieszka Józwik, Agnieszka Grasa, Jorge Universidad de Zaragoza (orcid)0000-0002-6870-0594 Przezdziecka-Dolyk, Joanna Siedlecki, Damian 5004 605 Universidad de Zaragoza Dpto. Ingeniería Mecánica Área Mec.Med.Cont. y Teor.Est. 13 (2025), 1504769 [11 pp.] Front. Bioeng. Biotechnol. Frontiers in Bioengineering and Biotechnology 2296-4185 2185936 http://zaguan.unizar.es/record/153041/files/texto_completo.pdf Versión publicada 2037966 http://zaguan.unizar.es/record/153041/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:153041 articulos driver 2025-10-17-14:36:38 ARTICLE