000153110 001__ 153110
000153110 005__ 20251017144623.0
000153110 0247_ $$2doi$$a10.1002/marc.202500029
000153110 0248_ $$2sideral$$a143565
000153110 037__ $$aART-2025-143565
000153110 041__ $$aeng
000153110 100__ $$aMartín-Martín, Javier
000153110 245__ $$aDegradable Ureido‐Polycarbonate Block Copolymers with a Complex UCST Thermoresponse
000153110 260__ $$c2025
000153110 5060_ $$aAccess copy available to the general public$$fUnrestricted
000153110 5203_ $$aIn this work, amphiphilic block copolymers (BCs) consisting of a hydrophilic poly(ethylene glycol) methyl ether (PEG) and a degradable polycarbonate block derived from 2,2‐bis(hydroxymethyl)propionic acid (bis‐MPA) with pendant ureido units, along with corresponding homopolycarbonates are described. Polymers are synthesized by combining ring opening polymerization (ROP) and thiol‐ene/yne functionalization to incorporate UCST‐promoting ureido groups. For homopolycarbonates, increasing the ureido groups density along the polymer chain facilitates the upper critical solution temperature (UCST)‐type thermoresponse in water. Because of their amphiphilic character, BCs form stable self‐assemblies either by direct dispersion in water, co‐solvent method or microfluidics. Upon heating, these self‐assemblies swell, and collapse due to extensive hydration of the polycarbonate block, rather than becoming solubilized. Thermoresponsiveness is analyzed in terms of the number of ureido groups in the polycarbonate for a given polycarbonate block length as well as the length of polycarbonate block. As a proof of concept, the potential of these self‐assemblies as thermoresponsive drug nanocarriers is evaluated, using curcumin as a hydrophobic model drug.
000153110 536__ $$9info:eu-repo/grantAgreement/ES/DGA/E47-23R$$9info:eu-repo/grantAgreement/ES/DGA/LMP 93-21$$9info:eu-repo/grantAgreement/ES/MICINN/PID2021-1261132NB-I00$$9info:eu-repo/grantAgreement/ES/MICIU/CEX2023-001286-S
000153110 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttps://creativecommons.org/licenses/by/4.0/deed.es
000153110 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000153110 700__ $$0(orcid)0000-0002-8677-3316$$aAbad, Miriam$$uUniversidad de Zaragoza
000153110 700__ $$aLópez de Pariza, Xabier
000153110 700__ $$aEzquerra, Tiberio A.
000153110 700__ $$aNogales, Aurora
000153110 700__ $$aSardón, Haritz
000153110 700__ $$0(orcid)0000-0002-6873-5244$$aSebastián, Víctor$$uUniversidad de Zaragoza
000153110 700__ $$0(orcid)0000-0002-0922-5615$$aOriol, Luis$$uUniversidad de Zaragoza
000153110 700__ $$0(orcid)0000-0001-5556-2172$$aPiñol, Milagros$$uUniversidad de Zaragoza
000153110 7102_ $$15005$$2555$$aUniversidad de Zaragoza$$bDpto. Ing.Quím.Tecnol.Med.Amb.$$cÁrea Ingeniería Química
000153110 7102_ $$12013$$2765$$aUniversidad de Zaragoza$$bDpto. Química Orgánica$$cÁrea Química Orgánica
000153110 773__ $$g(2025), 2500029 [13 pp.]$$pMacromol. rapid commun.$$tMacromolecular Rapid Communications$$x1022-1336
000153110 8564_ $$s3188796$$uhttps://zaguan.unizar.es/record/153110/files/texto_completo.pdf$$yVersión publicada
000153110 8564_ $$s2430658$$uhttps://zaguan.unizar.es/record/153110/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000153110 909CO $$ooai:zaguan.unizar.es:153110$$particulos$$pdriver
000153110 951__ $$a2025-10-17-14:22:35
000153110 980__ $$aARTICLE