153112 20251017144623.0 doi 10.1371/journal.pone.0320205 sideral 143572 ART-2025-143572 eng Dahaghin, Ali Effect of intraocular pressure on crystalline lens oscillations: a computational study using porcine eye model 2025 Access copy available to the general public Unrestricted This study addresses a crucial knowledge gap by investigating the impact of intraocular pressure (IOP) on the wobbling characteristics of the crystalline lens in an ex vivo setting. It utilizes previous validated computational porcine eye models, which offer anatomical and physiological similarities to the human eye. These models incorporate fluid-structure interaction (FSI) to simulate the mechanical interaction between the fluids of the eye and the solid structures. Simulations were conducted under constant mechanical properties and boundary conditions, allowing for precise quantification of lens wobbling behavior with varying IOP levels. Various trends in lens displacement were observed at various IOP levels, revealing significant variations in both magnitude and duration. The results demonstrate the central role of intraocular pressure in influencing lens overshooting during rotational motion, with potential clinical implications. The observed lens displacement patterns, particularly in conditions like glaucoma, underscore the importance of considering IOP as a critical factor in understanding ocular biomechanics. Beyond immediate biomechanical relevance, the study’s findings suggest the potential use of the Purkinje imaging system as a non-invasive method for IOP estimation based on lens overshoot as an “inverse solution” strategy. This non-invasive imaging technique offers a promising alternative to traditional methods, minimizing patient discomfort and potentially enhancing measurement precision. info:eu-repo/grantAgreement/EC/H2020/956720/EU/Opto-Biomechanical Eye Research Network/OBERON This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 956720-OBERON info:eu-repo/semantics/openAccess by https://creativecommons.org/licenses/by/4.0/deed.es info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Salimibani, Milad Boszczyk, Agnieszka Grasa, Jorge Universidad de Zaragoza (orcid)0000-0002-6870-0594 Siedlecki, Damian 5004 605 Universidad de Zaragoza Dpto. Ingeniería Mecánica Área Mec.Med.Cont. y Teor.Est. 20, 3 (2025), e0320205 [11 pp.] PLoS One PLoS ONE 1932-6203 895824 http://zaguan.unizar.es/record/153112/files/texto_completo.pdf Versión publicada 2451508 http://zaguan.unizar.es/record/153112/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:153112 articulos driver 2025-10-17-14:22:35 ARTICLE