000153176 001__ 153176
000153176 005__ 20251017144550.0
000153176 0247_ $$2doi$$a10.1007/s11136-025-03920-3
000153176 0248_ $$2sideral$$a143651
000153176 037__ $$aART-2025-143651
000153176 041__ $$aeng
000153176 100__ $$aBatallas, Daniela
000153176 245__ $$aBlood ammonia and eye-hand coordination negatively affect health-related quality of life in women with minimal hepatic encephalopathy
000153176 260__ $$c2025
000153176 5060_ $$aAccess copy available to the general public$$fUnrestricted
000153176 5203_ $$aPurpose: Minimal hepatic encephalopathy (MHE) is common in cirrhosis, leading to cognitive impairment and eye-hand coordination (EHC) alterations. Hyperammonemia plays a key role in MHE, contributing to motor and cognitive deficits. Elevated blood ammonia levels and impaired EHC correlate with neuropsychiatric dysfunction, yet their direct impact on health-related quality of life (HRQoL) is complex. This study examines the associations between blood ammonia, EHC, and HRQoL, and the moderating influence of sex on these associations.
Methods: Eighty-seven cirrhotic patients (67 male) and 23 healthy volunteers (11 male), aged 44–80 years, performed the Psychometric Hepatic Encephalopathy Score (PHES) for MHE diagnosis, the Vienna Test System, bimanual and visuomotor tests, and completed the SF-36 questionnaire to measure HRQoL. Blood samples were taken to test ammonia levels.
Results: Results indicated a significant association between elevated blood ammonia and impaired EHC among cirrhotic patients. However, increased blood ammonia and EHC did not directly predict HRQoL. Moderated moderation analysis revealed that women with MHE showed greater sensitivity to hyperammonemia and EHC deficits in tasks requiring fine motor control and stability skills (aiming, tapping, and bimanual coordination), which were linked to lower HRQoL in both physical and mental domains. In women without MHE, alterations in linear tracking were linked to worse HRQoL. These effects were not observed in men.
Conclusions: The findings underscore the sex-specific impacts of MHE, with women disproportionately affected by ammonia-related motor impairments and their subsequent influence on HRQoL. These results could contribute to developing targeted strategies to improve outcomes in this vulnerable population.
000153176 536__ $$9info:eu-repo/grantAgreement/ES/ISCIII/PI23-00062$$9info:eu-repo/grantAgreement/ES/MICINN/PID2020-119406GB-I00
000153176 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttps://creativecommons.org/licenses/by/4.0/deed.es
000153176 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000153176 700__ $$aGallego, Juan José
000153176 700__ $$aCasanova-Ferrer, Franc
000153176 700__ $$aFiorillo, Alessandra
000153176 700__ $$aRivas-Diaz, Pablo
000153176 700__ $$aLópez-Gramaje, Adrià
000153176 700__ $$aArenas, Yaiza M.
000153176 700__ $$aAparicio, Luis
000153176 700__ $$aEscudero-García, Desamparados
000153176 700__ $$aDurbán, Lucía
000153176 700__ $$aRios, María-Pilar
000153176 700__ $$aBenlloch, Salvador
000153176 700__ $$aUrios, Amparo
000153176 700__ $$0(orcid)0000-0003-3920-1099$$aHidalgo, Vanesa$$uUniversidad de Zaragoza
000153176 700__ $$aMontoliu, Carmina
000153176 700__ $$aSalvador, Alicia
000153176 7102_ $$14009$$2725$$aUniversidad de Zaragoza$$bDpto. Psicología y Sociología$$cÁrea Psicobiología
000153176 773__ $$g(2025), [14 pp.]$$pQual. life res.$$tQUALITY OF LIFE RESEARCH$$x0962-9343
000153176 8564_ $$s1060600$$uhttps://zaguan.unizar.es/record/153176/files/texto_completo.pdf$$yVersión publicada
000153176 8564_ $$s2213198$$uhttps://zaguan.unizar.es/record/153176/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000153176 909CO $$ooai:zaguan.unizar.es:153176$$particulos$$pdriver
000153176 951__ $$a2025-10-17-14:11:35
000153176 980__ $$aARTICLE