000153223 001__ 153223
000153223 005__ 20251017144649.0
000153223 0247_ $$2doi$$a10.1039/d4nr04990j
000153223 0248_ $$2sideral$$a143696
000153223 037__ $$aART-2025-143696
000153223 041__ $$aeng
000153223 100__ $$aMohan, Hugh
000153223 245__ $$aB/N-doped carbon nano-onions as nanocarriers for targeted breast cancer therapy
000153223 260__ $$c2025
000153223 5060_ $$aAccess copy available to the general public$$fUnrestricted
000153223 5203_ $$aCancer is one of the leading causes of death worldwide and represents a significant burden on global health systems. Many existing chemotherapy treatments come with severe side effects, ranging from hair loss to cardiotoxicity, and many types of cancer express chemotherapy resistance, such as triple-negative breast cancer. This study presents a novel boron/nitrogen-doped carbon nano-onion (BN-CNO) based nanocarrier system that can deliver doxorubicin (DOX) to cancer cells via a pH-dependent drug release mechanism. The nanocarrier formulation consists of a hyaluronic acid/phospholipid conjugate (HA-DMPE) that is non-covalently bound to the BN-CNOs upon which DOX is loaded via π–π stacking interactions. The HA-DMPE/BN-CNO/DOX system enhances the uptake and anticancer effects of DOX in MDA-MB-468 and MDA-MB-231 TNBC cells whilst reducing the cardiotoxicity of DOX in AC-16 human cardiomyocytes.
000153223 536__ $$9info:eu-repo/grantAgreement/ES/AEI/PID2023-151080NB-I00$$9info:eu-repo/grantAgreement/ES/DGA/E13-23R$$9info:eu-repo/grantAgreement/ES/MICINN-AEI/PRTR-C17.I1$$9info:eu-repo/grantAgreement/ES/MICINN/PID2019-104739GB-100
000153223 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttps://creativecommons.org/licenses/by/4.0/deed.es
000153223 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000153223 700__ $$aSalaroglio, Iris Chiara
000153223 700__ $$aBartkowski, Michal
000153223 700__ $$aCourtney, Kellyjean
000153223 700__ $$aAndreana, Ilaria
000153223 700__ $$aLimongi, Tania
000153223 700__ $$0(orcid)0000-0002-2071-9093$$aArenal, Raul
000153223 700__ $$aRiganti, Chiara
000153223 700__ $$aArpicco, Silvia
000153223 700__ $$aGiordani, Silvia
000153223 773__ $$pNanoscale$$tNanoscale$$x2040-3364
000153223 8564_ $$s2872941$$uhttps://zaguan.unizar.es/record/153223/files/texto_completo.pdf$$yVersión publicada
000153223 8564_ $$s2707914$$uhttps://zaguan.unizar.es/record/153223/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000153223 909CO $$ooai:zaguan.unizar.es:153223$$particulos$$pdriver
000153223 951__ $$a2025-10-17-14:35:43
000153223 980__ $$aARTICLE