000153226 001__ 153226
000153226 005__ 20250425150652.0
000153226 0247_ $$2doi$$a10.1038/s41598-025-95411-1
000153226 0248_ $$2sideral$$a143710
000153226 037__ $$aART-2025-143710
000153226 041__ $$aeng
000153226 100__ $$aZapater-Fajarí, Mariola
000153226 245__ $$aLoneliness and biomarkers of brain pathology in people with subjective cognitive decline
000153226 260__ $$c2025
000153226 5060_ $$aAccess copy available to the general public$$fUnrestricted
000153226 5203_ $$aLoneliness is a neuropsychiatric symptom that has been associated with cognitive impairment and dementia. We aimed to investigate whether depressive symptomatology and biomarkers of Alzheimer’s disease (AD) and cerebrovascular disease (CVD) are associated with loneliness. Secondly, we aimed to investigate whether loneliness, depressive symptomatology, and biomarkers of AD and CVD are associated with subjective cognitive decline (SCD). We included 215 cognitively unimpaired participants (70 y/o) with cerebrospinal fluid biomarkers, magnetic resonance imaging, and questionnaires for loneliness, depressive symptomatology, and SCD. For aim 1, our findings showed that CVD and depressive symptomatology were the most relevant measures to discriminate people with loneliness. For aim 2, a random forest classification model showed that loneliness contributed to discriminate individuals with SCD, but logistic regression showed that its partial predictive effect was non-significant when depressive symptomatology and AD biomarkers were included in the models. We conclude that loneliness is associated with SCD, CVD, and depressive symptomatology. Given the complex interplay between loneliness, depressive symptomatology, and SCD, more research is needed to fully clarify the unique role of each neuropsychiatric symptom in relation to biomarkers of brain pathology.
000153226 536__ $$9info:eu-repo/grantAgreement/ES/DGA/S31-23R$$9info:eu-repo/grantAgreement/ES/MICIU/PID2020-119406GB-I00
000153226 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000153226 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000153226 700__ $$aCrespo-Sanmiguel, Isabel
000153226 700__ $$aCedres, Nira
000153226 700__ $$aRydberg Sterner, Therese
000153226 700__ $$aRydén, Lina
000153226 700__ $$aSacuiu, Simona
000153226 700__ $$aWaern, Margda
000153226 700__ $$aZettergren, Anna
000153226 700__ $$aZetterberg, Henrik
000153226 700__ $$aBlennow, Kaj
000153226 700__ $$aKern, Silke
000153226 700__ $$0(orcid)0000-0003-3920-1099$$aHidalgo, Vanesa$$uUniversidad de Zaragoza
000153226 700__ $$aSalvador, Alicia
000153226 700__ $$aWestman, Eric
000153226 700__ $$aSkoog, Ingmar
000153226 700__ $$aFerreira, Daniel
000153226 7102_ $$14009$$2725$$aUniversidad de Zaragoza$$bDpto. Psicología y Sociología$$cÁrea Psicobiología
000153226 773__ $$g15, 1 (2025)$$pSci. rep. (Nat. Publ. Group)$$tScientific reports (Nature Publishing Group)$$x2045-2322
000153226 8564_ $$s1476209$$uhttps://zaguan.unizar.es/record/153226/files/texto_completo.pdf$$yVersión publicada
000153226 8564_ $$s2596590$$uhttps://zaguan.unizar.es/record/153226/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000153226 909CO $$ooai:zaguan.unizar.es:153226$$particulos$$pdriver
000153226 951__ $$a2025-04-25-13:27:38
000153226 980__ $$aARTICLE