153632 20251017144554.0 doi 10.1007/s12094-020-02295-w sideral 116844 ART-2020-116844 eng Dómine, M. SEOM clinical guidelines for the treatment of small-cell lung cancer (SCLC) (2019) 2020 Small-cell lung cancer (SCLC) accounts for 15% of lung cancers. Only one-third of patients are diagnosed at limited stage. The median survival remains to be around 15–20 months without significative changes in the strategies of treatment for many years. In stage I and IIA, the standard treatment is the surgery followed by adjuvant therapy with platinum–etoposide. In stage IIB–IIIC, the recommended treatment is early concurrent chemotherapy with platinum–etoposide plus thoracic radiotherapy followed by prophylactic cranial irradiation in patients without progression. However, in the extensive stage, significant advances have been observed adding immunotherapy to platinum–etoposide chemotherapy to obtain a significant increase in overall survival, constituting the new recommended standard of care. In the second-line treatment, topotecan remains as the standard treatment. Reinduction with platinum–etoposide is the recommended regimen in patients with sensitive relapse (= 3 months) and new drugs such as lurbinectedin and immunotherapy are new treatment options. New biomarkers and new clinical trials designed according to the new classification of SCLC subtypes defined by distinct gene expression profiles are necessary. info:eu-repo/semantics/closedAccess by https://creativecommons.org/licenses/by/4.0/deed.es 3.405 2020 ONCOLOGY 159 / 241 = 0.66 2020 Q3 T2 0.902 2020 Cancer Research 2020 Q2 Oncology 2020 Q2 Medicine (miscellaneous) 2020 Q2 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Moran, T. Isla, D. Martí, J. L. Sullivan, I. Provencio, M. Olmedo, M. E. Ponce, S. Blasco, A. Cobo, M. 22, 2 (2020), 245-255 Clin. transl. oncol. Clinical and Translational Oncology 1699-048X 843838 http://zaguan.unizar.es/record/153632/files/texto_completo.pdf Versión publicada 2232017 http://zaguan.unizar.es/record/153632/files/texto_completo.jpg?subformat=icon icon Versión publicada https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079002185&doi=10.1007%2fs12094-020-02295-w&partnerID=40&md5=ed9f62501c3a0c8fdfcc213ec47fe6a9 Texto completo de la revista oai:zaguan.unizar.es:153632 articulos driver 2025-10-17-14:12:36 ARTICLE