000153652 001__ 153652
000153652 005__ 20251017144557.0
000153652 0247_ $$2doi$$a10.1016/j.maturitas.2025.108268
000153652 0248_ $$2sideral$$a143777
000153652 037__ $$aART-2025-143777
000153652 041__ $$aeng
000153652 100__ $$aGarcía-Alfaro, Pascual
000153652 245__ $$aXerostomia and oral health-related quality of life in peri- and postmenopausal women
000153652 260__ $$c2025
000153652 5203_ $$aObjective
The menopausal transition triggers hormonal changes that can manifest in oral symptoms such as xerostomia, which can substantially impact women's quality of life. Our study examined the prevalence and severity of xerostomia and its association with menopausal status. Furthermore, we evaluated the impact of xerostomia on oral health-related quality of life in peri- and postmenopausal women.
Methods
This study was a cross-sectional investigation based on the results of a REDCap survey, involving 3211 women aged between 40 and 90 years. The survey recorded age, menopause status, age at menopause, smoking status, and being treated with xerogenic drugs and included two instruments: the Xerostomia Inventory, used to evaluate the oral symptoms; and the Oral Health Impact Profile-14 (OHIP-14), used to assess the related quality of life. Student's t-test, the chi-squared test, Pearson's correlation coefficient, and multivariable logistic and linear regressions were performed for data analysis. Odds ratio (OR), beta coefficient (β), and their 95 % confidence intervals (CIs) were applied to assess associations.
Results
The global prevalence of xerostomia was 71.2 %. The Xerostomia Inventory score correlated with the OHIP-14 score (r = 0.686; p = 0.000). Smoking was significantly associated with the probability of xerostomia (OR = 1.36; 95 % CI = 1.02–1.82), as were the following OHIP-14 domains: functional limitation (OR = 1.43; 95 % CI = 1.30–1.50), physical pain (OR = 1.17; 95 % CI = 1.06–1.29), psychological discomfort (OR = 1.21; 95 % CI = 1.13–1.29), physical disability (OR = 1.11; 95 % CI = 1.02–1.20), psychological disability (OR = 1.18; 95 % CI = 1.09–1.29), and social disability (OR = 1.15; 95 % CI = 1.01–1.32). There were no significant differences in the probability of xerostomia according to the menopausal status. In women with xerostomia the OHIP-14 score was higher than in women without xerostomia (β = 5.50; 95 % CI = 4.69–6.31).
Conclusions
Peri- and postmenopausal women have a high prevalence of xerostomia. There were no differences in the probability of xerostomia between peri- and postmenopausal women. There was a strong association between xerostomia symptoms and poor oral health-related quality of life.
000153652 540__ $$9info:eu-repo/semantics/closedAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/
000153652 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000153652 700__ $$0(orcid)0000-0002-2801-416X$$aPérez-López, Faustino R.
000153652 700__ $$aGarcía Martínez, Sandra
000153652 700__ $$aRodríguez, Ignacio
000153652 773__ $$g197 (2025), 108268 [7 pp.]$$pMaturitas$$tMaturitas$$x0378-5122
000153652 8564_ $$s1309137$$uhttps://zaguan.unizar.es/record/153652/files/texto_completo.pdf$$yVersión publicada
000153652 8564_ $$s2300603$$uhttps://zaguan.unizar.es/record/153652/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000153652 909CO $$ooai:zaguan.unizar.es:153652$$particulos$$pdriver
000153652 951__ $$a2025-10-17-14:13:35
000153652 980__ $$aARTICLE