000153658 001__ 153658 000153658 005__ 20251017144605.0 000153658 0247_ $$2doi$$a10.1016/j.neuro.2025.04.007 000153658 0248_ $$2sideral$$a143744 000153658 037__ $$aART-2025-143744 000153658 041__ $$aeng 000153658 100__ $$aRuiz-Sobremazas, Diego$$uUniversidad de Zaragoza 000153658 245__ $$aThe effects of oral gestational particulate matter 10 exposure: Insights into neurodevelopmental milestones, inhibitory control, adult sociability, and object recognition 000153658 260__ $$c2025 000153658 5060_ $$aAccess copy available to the general public$$fUnrestricted 000153658 5203_ $$aAir pollutants have been associated with various neurodevelopmental disorders, with several studies specifically linking Particulate Matter (PM) exposure to attentional and social deficits. This link is even more pronounced when exposure occurs during the prenatal period, as it can disrupt normal brain development. However, while social deficits have been extensively studied during adolescence, their impact on adult social behaviors remains largely unexplored. To investigate these effects, pregnant Wistar rats were exposed throughout gestation (GD1-GD21) to PM10 at a dosage of 200 μg/Kg/day diluted in PBS that was freely drunk. After birth, the pups were evaluated on developmental milestones such as weight progression, ocular opening, and muscular strength. In adulthood, inhibitory control was assessed using the Five Choice Serial Reaction Time Task (5-CSRTT), social behavior using the Three-Chambered Crawley’s Test (3-CT), and object recognition using the Novelty Object Recognition test (NOR). The results indicated that prenatal PM10 exposure is associated with higher birth weight and poorer performance in neuromuscular tests. However, no significant differences were observed in inhibitory control (5-CSRTT) or social behavior (3-CT). Interestingly, prenatally exposed rodents showed heightened novelty responses in the NOR test. In conclusion, gestational exposure to PM10 is related to differences in neurodevelopmental milestones, including weight and muscular strength. While it does not impact adult inhibitory control or social behavior, it influences novelty recognition in later life. 000153658 536__ $$9info:eu-repo/grantAgreement/ES/MICINN/PID2020-113812RB-C32/AEI/10.13039/501100011033 000153658 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc$$uhttps://creativecommons.org/licenses/by-nc/4.0/deed.es 000153658 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion 000153658 700__ $$aCoca, Mario 000153658 700__ $$aMorales-Navas, Miguel 000153658 700__ $$aRodulfo-Cardenas, Rocío 000153658 700__ $$0(orcid)0000-0001-6767-8252$$aLopez-Granero, Caridad$$uUniversidad de Zaragoza 000153658 700__ $$aColomina, Maria-Teresa 000153658 700__ $$aPerez-Fernandez, Cristian 000153658 700__ $$aSanchez-Santed, Fernando 000153658 7102_ $$14009$$2730$$aUniversidad de Zaragoza$$bDpto. Psicología y Sociología$$cÁrea Psicología Básica 000153658 773__ $$g108 (2025), 231-245$$pNeurotoxicology$$tNEUROTOXICOLOGY$$x0161-813X 000153658 8564_ $$s4282091$$uhttps://zaguan.unizar.es/record/153658/files/texto_completo.pdf$$yVersión publicada 000153658 8564_ $$s2408172$$uhttps://zaguan.unizar.es/record/153658/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada 000153658 909CO $$ooai:zaguan.unizar.es:153658$$particulos$$pdriver 000153658 951__ $$a2025-10-17-14:15:18 000153658 980__ $$aARTICLE