000153682 001__ 153682 000153682 005__ 20251017144625.0 000153682 0247_ $$2doi$$a10.1016/B978-0-12-394313-2.00004-4 000153682 0248_ $$2sideral$$a80463 000153682 037__ $$aART-2013-80463 000153682 041__ $$aeng 000153682 100__ $$0(orcid)0000-0002-9312-1519$$aBotello-Morte,L.$$uUniversidad de Zaragoza 000153682 245__ $$aFunctional Genomics of Metalloregulators in Cyanobacteria 000153682 260__ $$c2013 000153682 5060_ $$aAccess copy available to the general public$$fUnrestricted 000153682 5203_ $$aCyanobacterial metabolism relies on the activity of many enzymes and other proteins containing metal-rich cofactors that are absent in nonphotosynthetic organisms. Most of those micronutrients play key roles in or are associated to photosystems, respiratory electron transport chains and many enzymes involved in nitrogen metabolism. Since metal homeostasis is crucial for the ecological success of cyanobacteria, trace metal bio-uptake is strictly regulated by a number of metal-sensor proteins and regulatory proteins that often also contain metals. This chapter discusses functional studies undertaken to-date from a genomic point of view, as well as the main structural and mechanistic insights into the major families of metalloregulators in cyanobacteria. Reverse genetics, transcriptomics and other assays used for the identification of metal-regulated genes reveal interesting connections between metabolic networks and interactivity between major regulons. These data provide a better understanding of cyanobacterial physiology including maintenance of metal homeostasis, strategies to deal with different stresses and the basis of cyanotoxicity. 000153682 536__ $$9info:eu-repo/grantAgreement/ES/MICINN/BFU2009-07424 000153682 540__ $$9info:eu-repo/semantics/openAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/ 000153682 590__ $$a1.74$$b2013 000153682 591__ $$aPLANT SCIENCES$$b73 / 197 = 0.371$$c2013$$dQ2$$eT2 000153682 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/acceptedVersion 000153682 700__ $$0(orcid)0000-0002-0531-0943$$aGonzalez,A.$$uUniversidad de Zaragoza 000153682 700__ $$0(orcid)0000-0002-8181-2689$$aBes,M. T.$$uUniversidad de Zaragoza 000153682 700__ $$0(orcid)0000-0002-2742-3711$$aPeleato,M. L.$$uUniversidad de Zaragoza 000153682 700__ $$0(orcid)0000-0001-8644-4574$$aFillat,M. F.$$uUniversidad de Zaragoza 000153682 7102_ $$11002$$2412$$aUniversidad de Zaragoza$$bDpto. Bioq.Biolog.Mol. Celular$$cÁrea Fisiología Vegetal 000153682 7102_ $$11002$$2X$$aUniversidad de Zaragoza$$bDpto. Bioq.Biolog.Mol. Celular$$cProy. investigación DEA 000153682 7102_ $$11002$$2060$$aUniversidad de Zaragoza$$bDpto. Bioq.Biolog.Mol. Celular$$cÁrea Bioquímica y Biolog.Mole. 000153682 773__ $$g65 (2013), 107-156$$pAdv. Bot. Res.$$tADVANCES IN BOTANICAL RESEARCH$$x0065-2296 000153682 8564_ $$s1256432$$uhttps://zaguan.unizar.es/record/153682/files/texto_completo.pdf$$yPostprint 000153682 8564_ $$s475020$$uhttps://zaguan.unizar.es/record/153682/files/texto_completo.jpg?subformat=icon$$xicon$$yPostprint 000153682 909CO $$ooai:zaguan.unizar.es:153682$$particulos$$pdriver 000153682 951__ $$a2025-10-17-14:23:56 000153682 980__ $$aARTICLE