@article{JoverBravo:156427,
author = "Jover Bravo, Inés and Hernández Aínsa, Silvia",
title = "{Fabricación y evaluación de nanoestructuras de ADN
sensibles al pH para su uso en nanomedicina}",
year = "2018",
note = "The paramountcy of early diagnosis and good prognosis of
cancer has lead much of the on-going research towards the
development of novel technology and advanced materials.
Among others, DNA as building material present properties
such as biocompatibility and reliable design that make it
ideal for targeted tumour imaging. Recent studies have been
instrumental in strengthening programmable pH responsive
nanoswitches for their potential use as biosensors of
tumour microenvironment regardless of their liability to
suffer from quick clearance and nucleases degradation. The
aim of this research is to overcome the aforementioned
hindrances fabricating and evaluating new DNA
nanostructures incorporating the formerly studied
nanoswitches, together with ascertaining whether or not any
of these nanostructures could be suitable for their in vivo
application. To that end, both the structural and optical
characterization in addition to the stability to nucleases
assessment were performed. Ultimately, this essay has
served to suggest the complex 8SN3 as the best candidate
for further in vivo studies found on its resistance to
temperature and nucleases as well as its pH transition,
which best meets the in vivo sensing requirements for
bioimaging.",
}