000156540 001__ 156540
000156540 005__ 20251017144555.0
000156540 0247_ $$2doi$$a10.3390/genes11091050
000156540 0248_ $$2sideral$$a119540
000156540 037__ $$aART-2020-119540
000156540 041__ $$aeng
000156540 100__ $$aVázquez-Gómez, M.
000156540 245__ $$aMaternal transmission ratio distortion in two iberian pig varieties
000156540 260__ $$c2020
000156540 5060_ $$aAccess copy available to the general public$$fUnrestricted
000156540 5203_ $$aTransmission ratio distortion (TRD) is defined as the allele transmission deviation from the heterozygous parent to the offspring from the expected Mendelian genotypic frequencies. Although TRD can be a confounding factor in genetic mapping studies, this phenomenon remains mostly unknown in pigs, particularly in traditional breeds (i.e., the Iberian pig). We aimed to describe the maternal TRD prevalence and its genomic distribution in two Iberian varieties. Genotypes from a total of 247 families (dam and offspring) of Entrepelado (n = 129) and Retinto (n = 118) Iberian varieties were analyzed. The offspring were sired by both ungenotyped purebred Retinto and Entrepelado Iberian boars, regardless of the dam variety used. After quality control, 16, 246 single-nucleotide polymorphisms (SNPs) in the Entrepelado variety and 9744 SNPs in the Retinto variety were analyzed. Maternal TRD was evaluated by a likelihood ratio test under SNP-by-SNP, adapting a previous model solved by Bayesian inference. Results provided 68 maternal TRD loci (TRDLs) in the Entrepelado variety and 24 in the Retinto variety (q < 0.05), with mostly negative TRD values, increasing the transmission of the minor allele. In addition, both varieties shared ten common TRDLs. No strong evidence of biological effects was found in genes with TRDLs. However, some biological processes could be affected by TRDLs, such as embryogenesis at different levels and lipid metabolism. These findings could provide useful insight into the genetic mechanisms to improve the swine industry, particularly in traditional breeds.
000156540 536__ $$9info:eu-repo/grantAgreement/ES/MCIU-CDTI/IDI-20170304$$9info:eu-repo/grantAgreement/ES/MINECO/CGL2016-80155-R
000156540 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttps://creativecommons.org/licenses/by/4.0/deed.es
000156540 590__ $$a4.096$$b2020
000156540 591__ $$aGENETICS & HEREDITY$$b65 / 175 = 0.371$$c2020$$dQ2$$eT2
000156540 592__ $$a1.337$$b2020
000156540 593__ $$aGenetics (clinical)$$c2020$$dQ2
000156540 593__ $$aGenetics$$c2020$$dQ2
000156540 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000156540 700__ $$ade Hijas-Villalba, M.M.
000156540 700__ $$0(orcid)0000-0001-6256-5478$$aVarona, L.$$uUniversidad de Zaragoza
000156540 700__ $$aIbañez-Escriche, N.
000156540 700__ $$aRosas, J.P.
000156540 700__ $$aNegro, S.
000156540 700__ $$aNoguera, J.L.
000156540 700__ $$aCasellas, J.
000156540 7102_ $$11001$$2420$$aUniversidad de Zaragoza$$bDpto. Anatom.,Embri.Genét.Ani.$$cÁrea Genética
000156540 773__ $$g11, 9 (2020), 11091050 [16 pp.]$$pGenes (Basel)$$tGenes$$x2073-4425
000156540 8564_ $$s736947$$uhttps://zaguan.unizar.es/record/156540/files/texto_completo.pdf$$yVersión publicada
000156540 8564_ $$s2314241$$uhttps://zaguan.unizar.es/record/156540/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000156540 909CO $$ooai:zaguan.unizar.es:156540$$particulos$$pdriver
000156540 951__ $$a2025-10-17-14:13:03
000156540 980__ $$aARTICLE