000156549 001__ 156549
000156549 005__ 20251017144556.0
000156549 0247_ $$2doi$$a10.1080/09546634.2025.2487657
000156549 0248_ $$2sideral$$a143891
000156549 037__ $$aART-2025-143891
000156549 041__ $$aeng
000156549 100__ $$aDirschka, Thomas
000156549 245__ $$aReshaping treatment paradigm in actinic keratosis by using a modified Delphi questionnaire
000156549 260__ $$c2025
000156549 5060_ $$aAccess copy available to the general public$$fUnrestricted
000156549 5203_ $$aPurpose
Actinic keratosis (AK) is the main precursor of invasive cutaneous squamous cell carcinoma (cSCC). Since it is impossible to predict which lesions will progress to cSCC, early treatment of AK is crucial. Although AK treatments are effective, some are associated with local skin reactions that may impact treatment compliance and effectiveness. The aim of this modified Delphi study was to review the efficacy and safety of the different AK treatments, gain an understanding of the dermatologists’ perspectives on their use, and provide guidelines for clinical practice.
Materials and methods
This document corresponds to a modified Delphi consensus survey, based on a literature review and a single round of questionnaire.
Results
The Delphi questionnaire was completed by 73 dermatologists from Germany, Italy, and Spain. Agreement was achieved for 78% of statements, while 11% showed discrepancies or were rejected.
Conclusions
Key findings emphasize the importance of patient-centered approaches and treatment attributes beyond efficacy (e.g. tolerability or adherence). Understanding the mechanisms of action of treatments is vital for managing patients’ and clinicians’ expectations and optimizing outcomes. Alternative strategies for evaluating efficacy, including the Actinic Keratosis Area and Severity Index (AKASI) score and lesion reduction from baseline, were also highlighted.
000156549 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc$$uhttps://creativecommons.org/licenses/by-nc/4.0/deed.es
000156549 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000156549 700__ $$aArdigò, Marco
000156549 700__ $$aFargnoli, Maria Concetta
000156549 700__ $$aFerrándiz-Pulido, Carla
000156549 700__ $$0(orcid)0000-0001-8034-3617$$aGilaberte, Yolanda$$uUniversidad de Zaragoza
000156549 700__ $$aHadshiew, Ina
000156549 700__ $$aPeris, Ketty
000156549 700__ $$aSzeimies, Rolf-Markus
000156549 7102_ $$11007$$2183$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cÁrea Dermatología
000156549 773__ $$g36, 1 (2025), 2487657 [7 pp.]$$pJ. derm. treat.$$tJOURNAL OF DERMATOLOGICAL TREATMENT$$x0954-6634
000156549 8564_ $$s1166074$$uhttps://zaguan.unizar.es/record/156549/files/texto_completo.pdf$$yVersión publicada
000156549 8564_ $$s1236481$$uhttps://zaguan.unizar.es/record/156549/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000156549 909CO $$ooai:zaguan.unizar.es:156549$$particulos$$pdriver
000156549 951__ $$a2025-10-17-14:13:11
000156549 980__ $$aARTICLE