000156554 001__ 156554
000156554 005__ 20251017144557.0
000156554 0247_ $$2doi$$a10.1017/S0029665120006011
000156554 0248_ $$2sideral$$a119673
000156554 037__ $$aART-2020-119673
000156554 041__ $$aeng
000156554 100__ $$0(orcid)0000-0003-2005-8229$$aGonzalez-Gil, E.M.
000156554 245__ $$aAssociation between a metabolic syndrome score and high sensitivity C-reactive protein in European children: the IDEFICS study
000156554 260__ $$c2020
000156554 5060_ $$aAccess copy available to the general public$$fUnrestricted
000156554 5203_ $$aIntroduction
Metabolic syndrome (MetS) is a combination of risk factors that may be present already in childhood. MetS has been associated with inflammatory biomarkers such as high sensitivity C-reactive protein (hsCRP) in aduls. In 2014, Ahrens et al, published reference standards for a paediatric MetS score based on reference values from European children. The aim of this study is to assess longitudinally the relationship between a MetS score and hsCRP in a sample of European children.
Materials and Methods
Out of the baseline sample of the IDEFICS Study, 2913 children aged 2–9 years were included in this study. Inclusion criteria was having available data of waist circumference (WC), diastolic and systolic blood pressure (DBP, SBP), high density lipoprotein (HDL) cholesterol, triglycerides (TG), glucose and insulin, to calculate the homeostasis model assessment index (HOMA); and hs-CRP as a marker of inflammation, at baseline (T0) and two years later (T1). hs-CRP was categorized into two categories as some children had lower concentration than the detection limit of 0.02mg/dL. Student t-test and logistic regression were used to assess these associations. Logistic regression was adjusted by age, sex, body mass index (BMI), socioeconomic level and country.
Results
Differences of mean values of the components of the MetS and the two categories of hs-CRP were observed between both time points. Mean values of SBP, DBP, WC, TG and HOMA were significantly higher in children with a higher category of hsCRP (p < 0.005). In addition, MetS score was significantly higher in those with a higher category of hs-CRP (p < 0.001) at both measurement points, T0 and T1. Finally, logistic regression between components of MetS and categories of hs-CRP, at both time points, showed significant associations (p < 0.001) for WC (OR = 1.06 at T0 and OR = 1.04 at T1) and HDL (OR = 0.98 at T0 and OR = 0.98 at T1) and the MetS score (OR = 1.07) score at T1.
Discussion
The association between MetS and inflammation is already present in children. Out of the components of the MetS, WC and HDL were the ones more associated with an inflammatory state at two times points. Also the MetS score, but only at the follow-up, was associated with the hs-CRP. Therefore, in order to prevent the inflammatory state in childhood, efforts to improve the metabolic profile, specially WC and HDL, need to be made.
000156554 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttps://creativecommons.org/licenses/by/4.0/deed.es
000156554 590__ $$a6.297$$b2020
000156554 591__ $$aNUTRITION & DIETETICS$$b15 / 87 = 0.172$$c2020$$dQ1$$eT1
000156554 592__ $$a1.417$$b2020
000156554 593__ $$aNutrition and Dietetics$$c2020$$dQ1
000156554 593__ $$aMedicine (miscellaneous)$$c2020$$dQ1
000156554 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000156554 700__ $$aNappo, A.
000156554 700__ $$0(orcid)0000-0002-7297-6104$$aSantabarbara, J.$$uUniversidad de Zaragoza
000156554 700__ $$aWolters, M.
000156554 700__ $$aRusso, P.
000156554 700__ $$aDe Henauw, S.
000156554 700__ $$aVeidebaum, T.
000156554 700__ $$aMolnar, D.
000156554 700__ $$aAhrens, W.
000156554 700__ $$0(orcid)0000-0003-0454-653X$$aMoreno, L.$$uUniversidad de Zaragoza
000156554 7102_ $$11006$$2255$$aUniversidad de Zaragoza$$bDpto. Fisiatría y Enfermería$$cÁrea Enfermería
000156554 7102_ $$11011$$2615$$aUniversidad de Zaragoza$$bDpto. Microb.Ped.Radio.Sal.Pú.$$cÁrea Medic.Prevent.Salud Públ.
000156554 773__ $$g79, OCE2 (2020), E652$$pProc. Nutr. Soc.$$tPROCEEDINGS OF THE NUTRITION SOCIETY$$x0029-6651
000156554 8564_ $$s266144$$uhttps://zaguan.unizar.es/record/156554/files/texto_completo.pdf$$yVersión publicada
000156554 8564_ $$s2450689$$uhttps://zaguan.unizar.es/record/156554/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000156554 909CO $$ooai:zaguan.unizar.es:156554$$particulos$$pdriver
000156554 951__ $$a2025-10-17-14:13:27
000156554 980__ $$aARTICLE