000156596 001__ 156596
000156596 005__ 20251017144623.0
000156596 0247_ $$2doi$$a10.1038/s41598-025-98748-9
000156596 0248_ $$2sideral$$a143882
000156596 037__ $$aART-2025-143882
000156596 041__ $$aeng
000156596 100__ $$aNavarro-López, Belén
000156596 245__ $$aExploring the association between SNPs and facial morphology in a Spanish population
000156596 260__ $$c2025
000156596 5060_ $$aAccess copy available to the general public$$fUnrestricted
000156596 5203_ $$aUnderstanding and predicting human external phenotypes, particularly facial shape, is of great value for individual identification. However, facial morphology is a highly complex trait. Despite its complexity, recent genome wide association studies (GWAS) have shed light on potential SNPs associated with facial features, offering a first glimpse into the likely genetic background of individual appearance. In this paper we have selected a set of 116 candidate SNPs and studied their association with facial phenotypes in a Spanish population of 412 individuals, highlighting a wide spectrum of facial morphologies worthy of investigation. We performed canonical correlation analysis (CCA) between each SNP and the observed spacial variation in facial shape, from its representation by a dense mesh of 7160 quasi-landmarks, revealing significant associations within different facial segments. In particular, ten SNPs are highlighted for their strong association within this Spanish population, some of them uncovering correlations with novel facial regions. These findings underline the importance and usefulness of conducting candidate SNP studies, not only to validate existing associations but also to unveil novel correlations within subpopulations.
000156596 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttps://creativecommons.org/licenses/by/4.0/deed.es
000156596 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000156596 700__ $$aWilke, Franziska
000156596 700__ $$aSuárez-Ulloa, Victoria
000156596 700__ $$0(orcid)0000-0002-6869-1413$$aBaeta, Miriam
000156596 700__ $$aMartos-Fernández, Rubén
000156596 700__ $$aMoreno-López, Olatz
000156596 700__ $$aOlalde, Iñigo
000156596 700__ $$0(orcid)0000-0001-6469-9189$$aMartínez-Jarreta, Begoña$$uUniversidad de Zaragoza
000156596 700__ $$aJiménez, Susana
000156596 700__ $$aWalsh, Susan
000156596 700__ $$aMartinez de Pancorbo, Marian$$uUniversidad de Zaragoza
000156596 7102_ $$11012$$2613$$aUniversidad de Zaragoza$$bDpto. Farmac.Fisiol.y Med.L.F.$$cÁrea Medicina Legal y Forense
000156596 773__ $$g15, 1 (2025), 13826 [11 pp.]$$pSci. rep. (Nat. Publ. Group)$$tScientific reports (Nature Publishing Group)$$x2045-2322
000156596 8564_ $$s1566847$$uhttps://zaguan.unizar.es/record/156596/files/texto_completo.pdf$$yVersión publicada
000156596 8564_ $$s2673463$$uhttps://zaguan.unizar.es/record/156596/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000156596 909CO $$ooai:zaguan.unizar.es:156596$$particulos$$pdriver
000156596 951__ $$a2025-10-17-14:22:38
000156596 980__ $$aARTICLE