doi:10.1038/s41467-025-58426-wengCapelo-Avilés, Santiagode Fez-Febré, MabelBalestra, Salvador R. G.Cabezas-Giménez, JuanjoTomazini de Oliveira, RaianaGallo Stampino, Irene I.Vidal-Ferran, AntonGonzález-Cobos, JesúsLillo, VanesaFabelo, OscarEscudero-Adán, Eduardo C.Falvello, Larry R.Parra, José B.Rumori, PaoloTurnes Palomino, GemmaPalomino Cabello, CarlosGiancola, StefanoCalero, SofiaGalán-Mascarós, José RamónSelective adsorption of CO2 in TAMOF-1 for the separation of CO2/CH4 gas mixturesART-2025-143886TAMOF-1 is a robust, highly porous metal–organic framework built from Cu2+ centers linked by a L-histidine derivative. Thanks to its high porosity and homochirality, TAMOF-1 has shown interesting molecular recognition properties, being able to resolve racemic mixtures of small organic molecules in gas and liquid phases. Now, we have discovered that TAMOF-1 also offers a competitive performance as solid adsorbent for CO2 physisorption, offering promising CO2 adsorption capacity ( > 3.8 mmol g–1) and CO2/CH4 Ideal Adsorbed Solution Theory (IAST) selectivity ( > 40) at ambient conditions. Moreover, the material exhibits favorable adsorption kinetics under dynamic conditions, demonstrating good stability in high-humidity environments and minimal degradation in strongly acidic media. We have identified the key interactions of CO2 within the TAMOF-1 framework by a combination of structural (neutron diffraction), spectroscopic and theoretical analyses which conclude a dual-site adsorption mechanism with the majority of adsorbed CO2 molecules occupying the empty voids in the TAMOF-1 channels without strong, directional supramolecular interactions. This very weak dominant binding opens the possibility of a low energy regeneration process for convenient CO2 purification. These features identify TAMOF-1 as a viable solid-state adsorbent for the realization of affordable biogas upgrading2025http://zaguan.unizar.es/record/15660110.1038/s41467-025-58426-whttp://zaguan.unizar.es/record/156601oai:zaguan.unizar.es:156601info:eu-repo/grantAgreement/ES/AEI/FJC2018-035697-Iinfo:eu-repo/grantAgreement/ES/AEI/PID2020-115658GB-I00info:eu-repo/grantAgreement/ES/AEI/RYC2022-036070-Iinfo:eu-repo/grantAgreement/ES/MICINN/CEX2021-001214-Sinfo:eu-repo/grantAgreement/ES/MICINN/PDC2022-133214-I00info:eu-repo/grantAgreement/ES/MICINN/PID2021-124796OB-I00info:eu-repo/grantAgreement/ES/MICINN/PID2021-124880NB-I00Nature communications 16, 1 (2025), 3243 [15 pp.]by-nc-ndhttps://creativecommons.org/licenses/by-nc-nd/4.0/deed.esinfo:eu-repo/semantics/openAccess