000156626 001__ 156626 000156626 005__ 20251017144650.0 000156626 0247_ $$2doi$$a10.1177/14034948251333236 000156626 0248_ $$2sideral$$a143840 000156626 037__ $$aART-2025-143840 000156626 041__ $$aeng 000156626 100__ $$aLenning, Ole Bernt 000156626 245__ $$aDo genetic variants of the Y chromosome affect mortality from COVID-19 000156626 260__ $$c2025 000156626 5060_ $$aAccess copy available to the general public$$fUnrestricted 000156626 5203_ $$aAims: During the early stages of the COVID-19 pandemic, significant differences in mortality patterns emerged based on sex and geographical regions. While we were studying on the heredity of variants of the Y chromosome, we observed that regional variations in mortality rates appeared to correlate with the geographical distribution of certain variants of the Y chromosome. This observation led us to propose that some genes on the Y chromosome, with an influence on immune responses, may represent a confounding factor in the observed geographical mortality differences. Methods: In this analysis, we investigate the potential associations between COVID-19 morbidity and disease-specific mortality and specific Y chromosome variants. The study is based on publicly available pandemic data validated by state authorities or presented in scientific literature documented in PubMed and Medline. Results: We find that Y chromosome haplogroups in different populations exhibit wave-like patterns corresponding with persistent global disparities in COVID-19-related mortality. Conclusions: These findings warrant further research to uncover possible new pathophysiological mechanisms. 000156626 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttps://creativecommons.org/licenses/by/4.0/deed.es 000156626 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion 000156626 700__ $$aMyhre, Ronny 000156626 700__ $$aVadla, May Sissel 000156626 700__ $$aOmdal, Roald 000156626 700__ $$0(orcid)0000-0001-6469-9189$$aMartínez Jarreta, Begoña$$uUniversidad de Zaragoza 000156626 700__ $$aGómez Moreno, Ángel 000156626 700__ $$aDe Blas, Ignacio 000156626 700__ $$aBraut, Geir Sverre 000156626 7102_ $$11012$$2613$$aUniversidad de Zaragoza$$bDpto. Farmac.Fisiol.y Med.L.F.$$cÁrea Medicina Legal y Forense 000156626 773__ $$g1 (2025), 5 pp.$$pScand. J. Public Health$$tSCANDINAVIAN JOURNAL OF PUBLIC HEALTH$$x1403-4948 000156626 8564_ $$s527601$$uhttps://zaguan.unizar.es/record/156626/files/texto_completo.pdf$$yVersión publicada 000156626 8564_ $$s2494399$$uhttps://zaguan.unizar.es/record/156626/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada 000156626 909CO $$ooai:zaguan.unizar.es:156626$$particulos$$pdriver 000156626 951__ $$a2025-10-17-14:36:06 000156626 980__ $$aARTICLE