156626 20251017144650.0 doi 10.1177/14034948251333236 sideral 143840 ART-2025-143840 eng Lenning, Ole Bernt Do genetic variants of the Y chromosome affect mortality from COVID-19 2025 Access copy available to the general public Unrestricted Aims: During the early stages of the COVID-19 pandemic, significant differences in mortality patterns emerged based on sex and geographical regions. While we were studying on the heredity of variants of the Y chromosome, we observed that regional variations in mortality rates appeared to correlate with the geographical distribution of certain variants of the Y chromosome. This observation led us to propose that some genes on the Y chromosome, with an influence on immune responses, may represent a confounding factor in the observed geographical mortality differences. Methods: In this analysis, we investigate the potential associations between COVID-19 morbidity and disease-specific mortality and specific Y chromosome variants. The study is based on publicly available pandemic data validated by state authorities or presented in scientific literature documented in PubMed and Medline. Results: We find that Y chromosome haplogroups in different populations exhibit wave-like patterns corresponding with persistent global disparities in COVID-19-related mortality. Conclusions: These findings warrant further research to uncover possible new pathophysiological mechanisms. info:eu-repo/semantics/openAccess by https://creativecommons.org/licenses/by/4.0/deed.es info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Myhre, Ronny Vadla, May Sissel Omdal, Roald Martínez Jarreta, Begoña Universidad de Zaragoza (orcid)0000-0001-6469-9189 Gómez Moreno, Ángel De Blas, Ignacio Braut, Geir Sverre 1012 613 Universidad de Zaragoza Dpto. Farmac.Fisiol.y Med.L.F. Área Medicina Legal y Forense 1 (2025), 5 pp. Scand. J. Public Health SCANDINAVIAN JOURNAL OF PUBLIC HEALTH 1403-4948 527601 http://zaguan.unizar.es/record/156626/files/texto_completo.pdf Versión publicada 2494399 http://zaguan.unizar.es/record/156626/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:156626 articulos driver 2025-10-17-14:36:06 ARTICLE