156645 20251017144551.0 doi 10.3390/jcm14103434 sideral 143946 ART-2025-143946 eng Ioakeim-Skoufa, Ignatios (orcid)0000-0002-6518-749X Electronic Health Records: A Gateway to AI-Driven Multimorbidity Solutions—A Comprehensive Systematic Review 2025 Access copy available to the general public Unrestricted Background/Objectives: Artificial intelligence (AI) plays an important role in real-world health research. It can address the complexities of chronic diseases and their associated negative outcomes. This systematic review aims to identify the applications of AI that utilize real-world health data for populations with multiple chronic conditions. Methods: A systematic search was performed in MEDLINE and EMBASE following PRISMA guidelines. Studies were included if they applied AI methods using data from electronic health records for patients with multimorbidity. Results: Forty-four studies met the inclusion criteria. The review revealed AI applications identifying disease clusters, predicting comorbidities, and estimating health outcomes such as mortality, adverse drug reactions, and hospital readmissions. Commonly used AI techniques included clustering methods, XGBoost, random forest, and neural networks. These methods helped identify risk factors, predict disease progression, and optimize treatment plans. Conclusions: This study emphasizes the increasing role of AI in understanding and managing multimorbidity. Integrating AI into healthcare systems can enhance resource allocation, improve care delivery efficiency, and support personalized treatment strategies. However, further research is needed to overcome existing limitations, particularly the lack of standardized performance metrics, which affects model comparability. Future research should adhere to commonly recommended evaluation practices to improve reproducibility and meta-analysis. info:eu-repo/grantAgreement/ES/DGA-FEDER/B01-23R info:eu-repo/grantAgreement/ES/ISCIII/RD24-0005-0013 info:eu-repo/grantAgreement/ES/ISCIII-RICAPPS/RD21-0016-0019 info:eu-repo/semantics/openAccess by https://creativecommons.org/licenses/by/4.0/deed.es info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Cebollada-Herrera, Celeste Marín-Bárcena, Concepción Roque, Vitor Roque, Fátima Atkins, Kerry Hernández-Rodríguez, Miguel Ángel Aza-Pascual-Salcedo, Mercedes Fanlo-Villacampa, Ana Universidad de Zaragoza (orcid)0000-0001-8064-8138 Coelho, Helena Lasala-Aza, Carmen Ledesma-Calvo, Rubén Gimeno-Miguel, Antonio (orcid)0000-0002-5440-1710 Vicente-Romero, Jorge Universidad de Zaragoza (orcid)0000-0003-4629-6743 1012 315 Universidad de Zaragoza Dpto. Farmac.Fisiol.y Med.L.F. Área Farmacología 14, 10 (2025), 3434 [23 pp.] J. clin.med. Journal of Clinical Medicine 2077-0383 893373 http://zaguan.unizar.es/record/156645/files/texto_completo.pdf Versión publicada 2785251 http://zaguan.unizar.es/record/156645/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:156645 articulos driver 2025-10-17-14:11:50 ARTICLE