000156651 001__ 156651
000156651 005__ 20251017144556.0
000156651 0247_ $$2doi$$a10.1016/j.anireprosci.2025.107853
000156651 0248_ $$2sideral$$a143964
000156651 037__ $$aART-2025-143964
000156651 041__ $$aeng
000156651 100__ $$0(orcid)0000-0002-4670-3735$$aPeña-Delgado, Victoria
000156651 245__ $$aAntioxidant components of ram seminal plasma are influenced by age, season, and the RsaI polymorphism of the MTNR1A gene
000156651 260__ $$c2025
000156651 5060_ $$aAccess copy available to the general public$$fUnrestricted
000156651 5203_ $$aMelatonin regulates reproductive seasonality in sheep, and its concentration in the blood plasma is influenced by day length and age. It can act directly or by modulating antioxidant defense enzymes. The RsaI polymorphism (g.17355458 C > T) of the melatonin receptor MT1 gene (MTNR1A) has been associated with changes in ram semen and reproductive behavior. But it remains unknown how age and this polymorphism affect melatonin concentration and the activities of antioxidant defense enzymes in ram seminal plasma. The aim of this study was therefore to analyze the effect of the RsaI polymorphism on melatonin levels and the activities of catalase (CAT), glutathione reductase (GRD), and glutathione peroxidase (GPx) in the seminal plasma of young and adult rams carrying different MTNR1A genotypes. For this purpose, seminal plasma was obtained from 15 young (16-month-old) and 9 adult (5-year-old) genotyped rams, and melatonin levels and CAT, GRD, and GPx activities were assessed for a year. Adult rams had higher melatonin concentrations in their seminal plasma than young rams. Adult CC and CT rams had the highest melatonin levels during the reproductive season, whereas young rams showed no differences between seasons. Adult rams also showed higher levels of GRD and GPx activity during the reproductive season; however, young rams showed higher levels of GPx activity during the non-reproductive season than during the reproductive season. These findings highlight the importance of considering the animal age when analyzing ram seminal plasma and its components.
000156651 536__ $$9info:eu-repo/grantAgreement/ES/DGA/A07-23R$$9info:eu-repo/grantAgreement/ES/MICINN/PID2020-113239RB-I00
000156651 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-nd$$uhttps://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
000156651 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000156651 700__ $$0(orcid)0000-0003-3929-5064$$aCarvajal-Serna, Melissa
000156651 700__ $$0(orcid)0000-0002-9552-4709$$aNoya, Agustí
000156651 700__ $$aCanto, Francisco
000156651 700__ $$aErden, Pelin
000156651 700__ $$0(orcid)0000-0003-2827-3054$$aAbecia, José Alfonso$$uUniversidad de Zaragoza
000156651 700__ $$0(orcid)0000-0002-2312-6402$$aPérez-Pe, Rosaura$$uUniversidad de Zaragoza
000156651 700__ $$0(orcid)0000-0003-1997-4262$$aCasao, Adriana$$uUniversidad de Zaragoza
000156651 7102_ $$11002$$2819$$aUniversidad de Zaragoza$$bDpto. Bioq.Biolog.Mol. Celular$$cÁrea Zoología
000156651 7102_ $$12008$$2700$$aUniversidad de Zaragoza$$bDpto. Produc.Animal Cienc.Ali.$$cÁrea Producción Animal
000156651 773__ $$g277 (2025), 107853 [8 pp.]$$pAnim. reprod. sci.$$tAnimal Reproduction Science$$x0378-4320
000156651 8564_ $$s1839280$$uhttps://zaguan.unizar.es/record/156651/files/texto_completo.pdf$$yVersión publicada
000156651 8564_ $$s1892149$$uhttps://zaguan.unizar.es/record/156651/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000156651 909CO $$ooai:zaguan.unizar.es:156651$$particulos$$pdriver
000156651 951__ $$a2025-10-17-14:13:12
000156651 980__ $$aARTICLE