160783 20251017144622.0 doi 10.1371/journal.pone.0321811 sideral 143987 ART-2025-143987 eng Carpallo-Porcar, Beatriz ARACOV-02. Specialized nutritional intervention and telerehabilitation in patients with long COVID: Protocol of a randomized controlled trial 2025 Access copy available to the general public Unrestricted It is estimated that at least 10% of the population infected with SARS-CoV-2 develop Post COVID Condition, which is characterized by a diverse array of symptoms including dyspnea, fatigue, anxiety, depression, and deterioration in quality of life. The SARS-CoV-2 virus can trigger an excessive immune response, characterized by the release of pro-inflammatory cytokines including IL-6, IL-1, TNFα and reactive oxygen species. Specialized Pro Resolving Mediators (SPMs) (17-HAD, 14-HAD and 18_HEPE) that could be useful in Post COVID Condition modulating the inflammatory response. The objective is to determine the change in quality of life, inflammatory profile, functional capacity and emotional variables in a group taking a nutritional supplement (SPMs) plus a telerehabilitation programme. Methods. ARACOV-2 study is a double-blind, parallel-group, randomized control trial with two parallel interventions: Nutritional supplement and telerehabilitation vs placebo supplement and telerehabilitation. The primary endpoint will be quality of life (EQ-5L-5D). The intervention will last 12 weeks with a daily intake of omega-3 or placebo and a daily supervised rehabilitation programme using telerehabilitation. Discussion. This study suggests that SPMs supplementation combined with telerehabilitation may improve inflammation and symptoms like fatigue in Post COVID Condition patients. Both interventions have anti-inflammatory potential, and their combined use could enhance physical and mental health outcomes. This approach offers a promising strategy for managing Post COVID Condition symptoms. info:eu-repo/grantAgreement/ES/DGA/IDMF 2021-0009 info:eu-repo/semantics/openAccess by https://creativecommons.org/licenses/by/4.0/deed.es info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Jiménez-Sánchez, Carolina Calvo, Sandra Universidad de Zaragoza (orcid)0000-0002-1674-7788 Irún, Pilar Kolesnyk-Sumskaya, Elena Aller-Blanco, Ana Isabel Corral Beamonte, Esther del Universidad de Zaragoza (orcid)0000-0001-9815-358X 1007 610 Universidad de Zaragoza Dpto. Medicina, Psiqu. y Derm. Area Medicina 1006 413 Universidad de Zaragoza Dpto. Fisiatría y Enfermería Área Fisioterapia 20, 4 (2025), e0321811 [15 pp.] PLoS One PLoS ONE 1932-6203 1689131 http://zaguan.unizar.es/record/160783/files/texto_completo.pdf Versión publicada 2206375 http://zaguan.unizar.es/record/160783/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:160783 articulos driver 2025-10-17-14:22:29 ARTICLE