000160787 001__ 160787
000160787 005__ 20251017144553.0
000160787 0247_ $$2doi$$a10.1002/smll.202412282
000160787 0248_ $$2sideral$$a143986
000160787 037__ $$aART-2025-143986
000160787 041__ $$aeng
000160787 100__ $$aGoudarzi, Zahra
000160787 245__ $$aTwo‐dimensional polycyclodextrins for strong multivalent host‐guest interactions at biointerfaces
000160787 260__ $$c2025
000160787 5060_ $$aAccess copy available to the general public$$fUnrestricted
000160787 5203_ $$aWhile 2D polymers with aromatic backbones have been increasingly receiving interest from various scientific disciplines, their nonaromatic counterparts are less investigated. In this work, 2D poly(β‐cyclodextrin)s (2D‐CDs) with few hundred nanometers to millimeters lateral sizes and 0.7 nm thickness are synthesized using graphene and boron nitride as colloidal templates and used for multivalent host‐guest interactions with biological systems. Deposition of cyclodextrins on graphene and boron nitride templates followed by lateral crosslinking and template detachment resulted in 2D‐CDs with different physicochemical properties. The size of the 2D‐CDs is dominated by noncovalent interactions between cyclodextrins and templates. While an interaction energy of −224.3 kJ mol−1 at the interface between graphene and cyclodextrin led to few hundred nanometer 2D‐CDs, boron nitride with weaker interactions (−179.4 kJ mol−1) resulted in polymers with millimeters lateral sizes. The secondary hydroxyl groups of 2D‐CDs are changed to sodium sulfate, and 2D polymers with the ability of simultaneous host‐guest and electrostatic interactions with biosystems including vessel plaques and herpes simplex virus (HSV) are obtained. The sulfated 2D‐CDs (2D‐CDSs) show a high ability for virus binding (IC50 = 6 µg mL−1). Owing to their carbohydrate backbone, 2D‐CDs are novel heparin mimetics that can be formulated for efficient inhibition of viral infections.
000160787 536__ $$9info:eu-repo/grantAgreement/ES/AEI/CEX2023-001286-S$$9info:eu-repo/grantAgreement/ES/AEI/PID2023-151080NB-I00$$9info:eu-repo/grantAgreement/ES/DGA/E13-23R
000160787 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttps://creativecommons.org/licenses/by/4.0/deed.es
000160787 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000160787 700__ $$aMohammadi, Zahra
000160787 700__ $$aMaleki, Reza
000160787 700__ $$aBeyranvand, Siamak
000160787 700__ $$aNie, Chuanxiong
000160787 700__ $$aGholami, Mohammad Fardin
000160787 700__ $$aAkkaya, Özge
000160787 700__ $$aKalantari, Mahdieh
000160787 700__ $$aNemati, Mohammad
000160787 700__ $$aYousufvand, Fatemeh
000160787 700__ $$aShahverdi, Fatemeh
000160787 700__ $$aRashidipour, Marzieh
000160787 700__ $$aAhmadian, Zainab
000160787 700__ $$aDonskyi, Ievgen
000160787 700__ $$aNickl, Philip
000160787 700__ $$aBrzezinski, Marek
000160787 700__ $$aLudwig, Kai
000160787 700__ $$aRabe, Jürgen P.
000160787 700__ $$0(orcid)0000-0002-2071-9093$$aArenal, Raul
000160787 700__ $$aChong, Cheng
000160787 700__ $$aALL, Angelo H.
000160787 700__ $$aAdeli, Mohsen
000160787 773__ $$g(2025), 2412282 [12 pp.]$$pSmall$$tSmall$$x1613-6810
000160787 8564_ $$s11715536$$uhttps://zaguan.unizar.es/record/160787/files/texto_completo.pdf$$yVersión publicada
000160787 8564_ $$s2589450$$uhttps://zaguan.unizar.es/record/160787/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000160787 909CO $$ooai:zaguan.unizar.es:160787$$particulos$$pdriver
000160787 951__ $$a2025-10-17-14:12:25
000160787 980__ $$aARTICLE