Thyroid hormones in people with chronic obstructive pulmonary disease: A systematic review and meta-analysis
Fandos Vázquez, Pilar ; Díez-Manglano, Jesús (Universidad de Zaragoza)
Resumen: Objective: To determine the influence of COPD on thyroid hormone levels.
Methods: We performed a meta-analysis after conducting a literature search in PubMed, Embase, Web of Science, the Cochrane Library, ScienceDirect, and the Virtual Health Library from database inception to December 31st, 2023. We employed the inverse variance method with a random effects model to calculate the effect estimate as the mean difference (MD) and 95 % confidence interval (CI). We calculated the heterogeneity with the I2 statistic and performed a meta-regression analysis based on age, sex, and smoking status. The PROSPERO registry number was CRD42024492108.
Results: The meta-analysis included 25 studies with 1613 patients with COPD and 1792 controls. The pooled MD (95 %CI) for TSH and total T3 were −0.26 mUI/L (−0.46, −0.07); p = 0.009, and −0.15 pg/mL (−0.29, −0.00); p = 0.04 respectively. There was no difference for free T3 and T4 and for total T4 between patients and controls. Heterogeneity was high in all cases. The patients with acute exacerbation of COPD had lower levels of TSH, free and total T3, pooled MD for TSH -0.58 mIU/L (−0.86, −0.31); p < 0.001, for free T3 -0.80 pg/mL (-1.53, -0.31); p < 0.001 and for total T3 -0.21 ng/mL (-0.33, -0.08); p < 0.001. TSH and total T3 levels were lower in patients with more severe airflow obstruction. The meta-regression analysis showed that the percentage of males and smokers in each study could explain the heterogeneity in T4 values.
Conclusions: TSH and T3 levels are decreased in patients with COPD, particularly in severe stages and during acute exacerbations.
Idioma: Inglés
DOI: 10.1016/j.rmed.2025.108103
Año: 2025
Publicado en: Respiratory Medicine 242 (2025), 108103 [8 pp.]
ISSN: 0954-6111
Tipo y forma: Artículo (Versión definitiva)
Área (Departamento): Area Medicina (Dpto. Medicina, Psiqu. y Derm.)
Debe reconocer adecuadamente la autoría, proporcionar un enlace a la licencia e indicar si se han realizado cambios. Puede hacerlo de cualquier manera razonable, pero no de una manera que sugiera que tiene el apoyo del licenciador o lo recibe por el uso que hace. No puede utilizar el material para una finalidad comercial. Si remezcla, transforma o crea a partir del material, no puede difundir el material modificado.
Fecha de embargo : 2026-04-14
Exportado de SIDERAL (2025-10-17-14:13:49)
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Methods: We performed a meta-analysis after conducting a literature search in PubMed, Embase, Web of Science, the Cochrane Library, ScienceDirect, and the Virtual Health Library from database inception to December 31st, 2023. We employed the inverse variance method with a random effects model to calculate the effect estimate as the mean difference (MD) and 95 % confidence interval (CI). We calculated the heterogeneity with the I2 statistic and performed a meta-regression analysis based on age, sex, and smoking status. The PROSPERO registry number was CRD42024492108.
Results: The meta-analysis included 25 studies with 1613 patients with COPD and 1792 controls. The pooled MD (95 %CI) for TSH and total T3 were −0.26 mUI/L (−0.46, −0.07); p = 0.009, and −0.15 pg/mL (−0.29, −0.00); p = 0.04 respectively. There was no difference for free T3 and T4 and for total T4 between patients and controls. Heterogeneity was high in all cases. The patients with acute exacerbation of COPD had lower levels of TSH, free and total T3, pooled MD for TSH -0.58 mIU/L (−0.86, −0.31); p < 0.001, for free T3 -0.80 pg/mL (-1.53, -0.31); p < 0.001 and for total T3 -0.21 ng/mL (-0.33, -0.08); p < 0.001. TSH and total T3 levels were lower in patients with more severe airflow obstruction. The meta-regression analysis showed that the percentage of males and smokers in each study could explain the heterogeneity in T4 values.
Conclusions: TSH and T3 levels are decreased in patients with COPD, particularly in severe stages and during acute exacerbations.
Idioma: Inglés
DOI: 10.1016/j.rmed.2025.108103
Año: 2025
Publicado en: Respiratory Medicine 242 (2025), 108103 [8 pp.]
ISSN: 0954-6111
Tipo y forma: Artículo (Versión definitiva)
Área (Departamento): Area Medicina (Dpto. Medicina, Psiqu. y Derm.)
Debe reconocer adecuadamente la autoría, proporcionar un enlace a la licencia e indicar si se han realizado cambios. Puede hacerlo de cualquier manera razonable, pero no de una manera que sugiera que tiene el apoyo del licenciador o lo recibe por el uso que hace. No puede utilizar el material para una finalidad comercial. Si remezcla, transforma o crea a partir del material, no puede difundir el material modificado.Fecha de embargo : 2026-04-14
Exportado de SIDERAL (2025-10-17-14:13:49)
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Artículos > Artículos por área > Medicina
Registro creado el 2025-05-30, última modificación el 2025-10-17