000160920 001__ 160920
000160920 005__ 20251017144624.0
000160920 0247_ $$2doi$$a10.1007/s10654-025-01229-6
000160920 0248_ $$2sideral$$a144099
000160920 037__ $$aART-2025-144099
000160920 041__ $$aeng
000160920 100__ $$aHernáez, Álvaro
000160920 245__ $$aCohort profile: the CORDELIA study (Collaborative cOhorts Reassembled Data to study mEchanisms and Longterm Incidence of chronic diseAses)
000160920 260__ $$c2025
000160920 5060_ $$aAccess copy available to the general public$$fUnrestricted
000160920 5203_ $$aThe CORDELIA Study (Collaborative Cohorts Reassembled Data to Study Mechanisms and Long-term Incidence of Chronic Diseases) combines 35 Spanish population cohorts to investigate the clinical, environmental, genetic, and omics determinants of cardiovascular disease in the Southern European population. It aims to conduct the largest genome-wide association study to date on cardiovascular disease in this population, improve predictions of cardiovascular incidence using genomic and clinical data, and identify subgroups that would benefit most from targeted pharmacological and lifestyle interventions. CORDELIA includes 196,632 individuals (ages 18–84, 54% female, 96% born in Spain, 20% with higher education, recruited from 1989 to 2020, with follow-up periods ranging from 5 to 30 years), with DNA samples available for 117,342 participants (60%). Of the participants, 24% were current smokers, 43% hypertensive, 11% diabetic, 15% medicated with lipid-lowering drugs, 44% overweight, and 27% obese. If not already available, genotyping is being performed using the Axiom™ Spain Biobank array (~ 750,000 variants, including 115,000 specific and 50,000 rare functional variants from the Spanish population). The cohort also includes incident events (coronary heart disease, stroke, heart failure, peripheral artery disease, hypertension, diabetes); date and cause of death; and harmonized data on risk factors (body mass index, waist circumference, lipid profile, blood pressure, glucose, creatinine), lifestyle (smoking, physical activity, diet, alcohol), and socioeconomic status. 99,019 participants (50%) also provide plasma samples. CORDELIA will significantly contribute to understanding the complex interplay of risk factors contributing to cardiovascular disease and advance the fields of precision medicine and public health in Southern European individuals.
000160920 536__ $$9info:eu-repo/grantAgreement/ES/ISCIII/CP21-00040$$9info:eu-repo/grantAgreement/ES/ISCIII/CP21-00163$$9info:eu-repo/grantAgreement/ES/ISCIII PMP22-00033
000160920 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttps://creativecommons.org/licenses/by/4.0/deed.es
000160920 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000160920 700__ $$aCamps-Vilaró, Anna
000160920 700__ $$aPolo-Alonso, Sara
000160920 700__ $$aSubirana, Isaac
000160920 700__ $$aRamos, Rafel
000160920 700__ $$ade Cid, Rafael
000160920 700__ $$aRodríguez-Artalejo, Fernando
000160920 700__ $$aElosua, Roberto
000160920 700__ $$aChirlaque, M. Dolores
000160920 700__ $$aAmiano, Pilar
000160920 700__ $$aBermúdez-López, Marcelino
000160920 700__ $$aGuevara, Marcela
000160920 700__ $$aCinza-Sanjurjo, Sergio
000160920 700__ $$aSánchez, María-José
000160920 700__ $$ade León, Antonio Cabrera
000160920 700__ $$0(orcid)0000-0003-3963-0846$$aLaclaustra, Martín$$uUniversidad de Zaragoza
000160920 700__ $$aRojo-Martínez, Gemma
000160920 700__ $$aGuembe-Suescun, María J.
000160920 700__ $$aPérez-Gómez, Beatriz
000160920 700__ $$aVega-Alonso, Tomás
000160920 700__ $$aTorán-Monserrat, Pere
000160920 700__ $$aLora-Pablos, David
000160920 700__ $$aHuerta, José María
000160920 700__ $$aValdivielso, José M.
000160920 700__ $$aDégano, Irene R.
000160920 700__ $$aFélix-Redondo, Francisco J.
000160920 700__ $$aGandarillas, Ana María
000160920 700__ $$aValdés, Sergio
000160920 700__ $$aMundet-Tuduri, Xavier
000160920 700__ $$aSánchez, Pedro L.
000160920 700__ $$aMartín-Sánchez, Vicente
000160920 700__ $$aRigo, Fernando
000160920 700__ $$aAlonso-Sampedro, Manuela
000160920 700__ $$aMoreno-Iribas, Conchi
000160920 700__ $$aMartín-Escudero, Juan Carlos
000160920 700__ $$aDelgado, Elías
000160920 700__ $$aGrau, Maria
000160920 700__ $$aUrrutia, Inés
000160920 700__ $$aOvejero, Diana
000160920 700__ $$aQuintela, Inés
000160920 700__ $$aMartí-Lluch, Ruth
000160920 700__ $$aBlay, Natalia
000160920 700__ $$aBanegas, José R.
000160920 700__ $$aTizón-Marcos, Helena
000160920 700__ $$aGómez, Jesús Humberto
000160920 700__ $$aAizpurua, Amaia
000160920 700__ $$aCastro-Boqué, Eva
000160920 700__ $$aDelfrade, Josu
000160920 700__ $$aPrieto-Díaz, Miguel Ángel
000160920 700__ $$aRodríguez-Barranco, Miguel
000160920 700__ $$aAlmeida-González, Delia
000160920 700__ $$0(orcid)0000-0003-0604-5042$$aMoreno-Franco, Belén$$uUniversidad de Zaragoza
000160920 700__ $$aOualla-Bachiri, Wasima
000160920 700__ $$aSayón-Orea, Carmen
000160920 700__ $$aPlans-Beriso, Elena
000160920 700__ $$aLozano, José Eugenio
000160920 700__ $$aLópez-Lifante, Víctor M.
000160920 700__ $$aCancelas-Navia, Pilar
000160920 700__ $$aCabrera-Castro, Natalia
000160920 700__ $$aCambray, Serafí
000160920 700__ $$aZacarías-Pons, Lluís
000160920 700__ $$aFernández-Bergés, Daniel
000160920 700__ $$aDonoso-Navarro, Encarnación
000160920 700__ $$aMaldonado-Araque, Cristina
000160920 700__ $$aFranch-Nadal, Josep
000160920 700__ $$aDorado-Díaz, Pedro Ignacio
000160920 700__ $$aVillarín-Castro, Alejandro
000160920 700__ $$aFrontera-Juan, Guillem
000160920 700__ $$aGude, Francisco
000160920 700__ $$aAndueza, Naroa
000160920 700__ $$aTéllez-Plaza, María
000160920 700__ $$aAres-Blanco, Jessica
000160920 700__ $$aCruz, Raquel
000160920 700__ $$aRibas-Aulinas, Marc
000160920 700__ $$aBarretina, Jordi
000160920 700__ $$aGuallar-Castillón, Pilar
000160920 700__ $$aCaínzos-Achirica, Miguel
000160920 700__ $$aColorado-Yohar, Sandra Milena
000160920 700__ $$aLlorente, Adrián
000160920 700__ $$aDiaz-Tocados, Juan Miguel
000160920 700__ $$aArdanaz, Eva
000160920 700__ $$aMicó-Pérez, Rafael Manuel
000160920 700__ $$aFernandez-Martinez, Nicolás Francisco
000160920 700__ $$adel Cristo Rodríguez-Pérez, María
000160920 700__ $$aCenarro, Ana
000160920 700__ $$aCalle-Pascual, Alfonso L.
000160920 700__ $$aMarrugat, Jaume
000160920 7102_ $$11007$$2610$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Medicina
000160920 7102_ $$11011$$2615$$aUniversidad de Zaragoza$$bDpto. Microb.Ped.Radio.Sal.Pú.$$cÁrea Medic.Prevent.Salud Públ.
000160920 773__ $$g(2025), [19 pp.]$$pEur. j. epidemiol.$$tEuropean Journal of Epidemiology$$x0393-2990
000160920 8564_ $$s1078456$$uhttps://zaguan.unizar.es/record/160920/files/texto_completo.pdf$$yVersión publicada
000160920 8564_ $$s2356332$$uhttps://zaguan.unizar.es/record/160920/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
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000160920 951__ $$a2025-10-17-14:23:20
000160920 980__ $$aARTICLE