An organometallic approach to sub-2 nm thiolate-protected Au nanoclusters with enhanced catalytic and therapeutic properties

del-Campo, Irene ; Sorroche, Alba ; Allen, Nina ; Ghirardello, Mattia (Universidad de Zaragoza) ; Corzana, Francisco ; Galán, M. Carmen ; Monge, Miguel ; López-de-Luzuriaga, José M.

Resumen: Thiolate-protected gold nanoclusters (AuNCs) of sub-2 nm size have been synthesized through a novel bottom-up approach using the organometallic precursor [Au(C6F5)(tht)] (tht = tetrahydrothiophene) in a one-pot reaction under mild conditions. This protocol is simple, rapid (1 h), versatile (applicable to thiolate ligands of varying molecular sizes), and reproducible, yielding AuNCs with low size dispersion. Furthermore, the resulting nanomaterials exhibited remarkable catalytic activity, effectively reducing the pollutant 4-nitrophenol to 4-aminophenol, as well as promising photothermal and photodynamic properties upon exposure to an 808 nm laser, converting light into thermal energy and generating reactive oxygen species (ROS). Additionally, AuNCs stabilized with a nonapeptide demonstrated efficient catalase-like activity, thereby potentially enhancing the efficacy of photodynamic therapy. The cytotoxic effects against cancer (HeLa) and healthy cells (HDF) were also evaluated, showing greater selectivity for HeLa cells, with higher toxicity and increased ROS generation.

Idioma: Inglés

DOI: 10.1039/d5na00123d

Año: 2025

Publicado en: Nanoscale Advances (2025), [8 pp.]
ISSN: 2516-0230

Financiación: info:eu-repo/grantAgreement/ES/AEI/PID2022-139739NB-I00
Financiación: info:eu-repo/grantAgreement/EC/H2020/101034288/EU/International Fellowship Programme for Talent Attraction to the Campus of International Excellence Campus Iberus/IberusExperience
Financiación: info:eu-repo/grantAgreement/ES/MICINN/PID2021-127622OB-I00

Tipo y forma: Artículo (Versión definitiva)

Área (Departamento): Área Química Orgánica (Dpto. Química Orgánica)