000160979 001__ 160979
000160979 005__ 20251017144559.0
000160979 0247_ $$2doi$$a10.1016/j.freeradbiomed.2025.03.044
000160979 0248_ $$2sideral$$a144182
000160979 037__ $$aART-2025-144182
000160979 041__ $$aeng
000160979 100__ $$aRodriguez-Hernandez, Zulema
000160979 245__ $$aNon-genetic and genetic determinants of serum selenium and selenium species in the Aragon Workers Health Study
000160979 260__ $$c2025
000160979 5203_ $$aUnderstanding potential determinants of selenium biomarkers can help to unravel selenium health effects. We evaluated the contribution of non-genetic (sociodemographic and lifestyle) and genetic factors to serum selenium biomarkers and selenium species (quantified as selenium) including selenium in glutathione peroxidase (GPx), selenoprotein P (SeP), selenoalbumin (SeAlb) and total selenometabolites (Se-metabolites) in the Aragon Workers Health Study (AWHS), a predominantly male cohort of car assembly factory workers in Spain. Total serum selenium and selenium species were measured by HPLC/ICP-QQQ-MS in 1624 AWHS participants. Blood and urine selenium, measured by ICP-MS, were available in a subset. A Healthy Lifestyle Score (HLS) included Mediterranean diet, physical activity, smoking, BMI and alcohol intake. Candidate gene and genome-wide discovery analyses (CGA and GDA, respectively) were based on TOPMed imputed SNPs. In sex and age-adjusted models, overall HLS, physical activity, and specific foods intake showed positive associations with serum total selenium, SeAlb and Se-metabolites concentrations. The associations between smoking status and BMI with total serum selenium; age, smoking status, BMI and meat intake with SeAlb; and smoking status with Se-metabolites, were inverse. In the GDA, we identified 20, 24, 21, 26, 16, 20 and 68 independent genetic loci for serum total selenium, GPx, SeP, SeAlb, Se-metabolites, and total blood and urine selenium, respectively, with some overlapping genes also relevant in the CGA. Enrichment analysis pointed to biological pathways including circadian rhythm regulation, immune system processes, signaling and receptor- and transporter-related pathways. The explained variability of selenium markers ranged from 15 % for SeP to 21 % for SeAlb and from 0.2 % for SeP to 3.5 % for SeAlb in environmental determinants-adjusted models with and without the specific selenium biomarker polygenic score, respectively. While the genetic contribution is substantial, selenium status might be influenced by reinforced healthy lifestyle interventions. Follow-up genetic studies to evaluate selenium health consequences are granted.
000160979 536__ $$9info:eu-repo/grantAgreement/ES/AEI/PID2019-108973RB-C21$$9info:eu-repo/grantAgreement/ES/AEI/PID2019-108973RB-C22$$9info:eu-repo/grantAgreement/ES/AEI/PID2023-147163OB-C21$$9info:eu-repo/grantAgreement/ES/AEI/PID2023-147163OB-C22$$9info:eu-repo/grantAgreement/ES/ISCIII-ERDF/CIBERCV-CB16-11-00451$$9info:eu-repo/grantAgreement/ES/ISCIII/PICIII22-00029$$9info:eu-repo/grantAgreement/ES/ISCIII/PI15-00071$$9info:eu-repo/grantAgreement/ES/ISCIII/FIS/PI19-00694$$9info:eu-repo/grantAgreement/ES/MICINN-ISCIII/PI18-01777
000160979 540__ $$9info:eu-repo/semantics/closedAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/
000160979 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000160979 700__ $$aParedes-Douton, Anabel
000160979 700__ $$aGalvez-Fernandez, Marta
000160979 700__ $$aGrau-Perez, Maria
000160979 700__ $$aSotos-Prieto, Mercedes
000160979 700__ $$aRentero-Garrido, Pilar
000160979 700__ $$aGonzalez-Estecha, Montserrat
000160979 700__ $$aLlorente-Ballesteros, Maria Teresa
000160979 700__ $$aGomez-Ariza, Jose L.
000160979 700__ $$aCallejon-Leblic, Belen
000160979 700__ $$aFernandez-Navarro, Pablo
000160979 700__ $$0(orcid)0000-0003-3963-0846$$aLaclaustra, Martin$$uUniversidad de Zaragoza
000160979 700__ $$aCenarro, Ana
000160979 700__ $$0(orcid)0000-0001-7043-0952$$aCiveira, Fernando$$uUniversidad de Zaragoza
000160979 700__ $$aGlabonjat, Ronald A.
000160979 700__ $$aMonleon, Daniel
000160979 700__ $$aPastor-Barriuso, Roberto
000160979 700__ $$0(orcid)0000-0003-0604-5042$$aMoreno-Franco, Belen$$uUniversidad de Zaragoza
000160979 700__ $$aGarcia-Barrera, Tamara
000160979 700__ $$aTellez-Plaza, Maria
000160979 7102_ $$11007$$2610$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Medicina
000160979 7102_ $$11011$$2615$$aUniversidad de Zaragoza$$bDpto. Microb.Ped.Radio.Sal.Pú.$$cÁrea Medic.Prevent.Salud Públ.
000160979 773__ $$g233 (2025), 365-377$$pFree radic. biol. med.$$tFREE RADICAL BIOLOGY AND MEDICINE$$x0891-5849
000160979 8564_ $$s2152841$$uhttps://zaguan.unizar.es/record/160979/files/texto_completo.pdf$$yVersión publicada
000160979 8564_ $$s2422041$$uhttps://zaguan.unizar.es/record/160979/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000160979 909CO $$ooai:zaguan.unizar.es:160979$$particulos$$pdriver
000160979 951__ $$a2025-10-17-14:13:49
000160979 980__ $$aARTICLE