000160985 001__ 160985
000160985 005__ 20251017144615.0
000160985 0247_ $$2doi$$a10.1016/j.pbb.2025.174039
000160985 0248_ $$2sideral$$a144149
000160985 037__ $$aART-2025-144149
000160985 041__ $$aeng
000160985 100__ $$aMartínez-Caballero, María Ángeles
000160985 245__ $$aEnhanced novelty-seeking after early adolescent exposure to vicarious social defeat predicts the vulnerability of female mice to cocaine reward
000160985 260__ $$c2025
000160985 5060_ $$aAccess copy available to the general public$$fUnrestricted
000160985 5203_ $$aStressful experiences can have a serious impact on adolescents, as the process of brain maturation, particularly of the prefrontal cortex, takes place during this developmental period. In animal models, male mice exposed to social defeat during early or late adolescence show increased vulnerability to cocaine reward, but this effect has only been studied in late adolescent female mice exposed to Vicarious Intermittent Social Defeat (VISD). The aim of the present study was to investigate the biochemical and behavioural effects of exposure to VISD during early adolescence in female mice. VISD only induced anxiety-like symptoms in the elevated plus maze (EPM) and increased novelty-seeking behaviour in the hole-board test. Furthermore, the behavioural profile of VISD-exposed mice in these tests was associated with their vulnerability or resilience to cocaine reward in adulthood. Female mice that exhibited a higher frequency of entries in the closed arms of the EPM and a lower latency of dips in the hole-board subsequently acquired cocaine-induced conditioned place preference. Thus, exposure of female mice to VISD during early adolescence also induced short-term changes that increased sensitivity to cocaine reward in susceptible individuals.
000160985 536__ $$9info:eu-repo/grantAgreement/ES/MICINN/PID2020-118945RB-I00
000160985 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-nd$$uhttps://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
000160985 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000160985 700__ $$aCalpe-López, Claudia
000160985 700__ $$aGarcía-Pardo, María Pilar$$uUniversidad de Zaragoza
000160985 700__ $$aArenas, María Carmen
000160985 700__ $$aRubia Ortí, Jose Enrique de la
000160985 700__ $$aBenlloch, María
000160985 700__ $$aManzanedo, Carmen
000160985 700__ $$aAguilar, María Asunción
000160985 7102_ $$14009$$2735$$aUniversidad de Zaragoza$$bDpto. Psicología y Sociología$$cÁrea Psicolog.Evolut.Educac
000160985 773__ $$g253 (2025), 174039 [9 pp.]$$pPharmacol. biochem. behav.$$tPHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR$$x0091-3057
000160985 8564_ $$s1302934$$uhttps://zaguan.unizar.es/record/160985/files/texto_completo.pdf$$yVersión publicada
000160985 8564_ $$s2701425$$uhttps://zaguan.unizar.es/record/160985/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000160985 909CO $$ooai:zaguan.unizar.es:160985$$particulos$$pdriver
000160985 951__ $$a2025-10-17-14:18:58
000160985 980__ $$aARTICLE