000160986 001__ 160986 000160986 005__ 20251017144615.0 000160986 0247_ $$2doi$$a10.1161/ATVBAHA.125.319221 000160986 0248_ $$2sideral$$a144151 000160986 037__ $$aART-2025-144151 000160986 041__ $$aeng 000160986 100__ $$aSanghvi, Mihir M. 000160986 245__ $$aUsing Genomics to Develop Personalized Cardiovascular Treatments 000160986 260__ $$c2025 000160986 5203_ $$aAdvances in genomic technologies have significantly enhanced our understanding of both monogenic and polygenic etiologies of cardiovascular disease. In this review, we explore how the utilization of genomic information is bringing personalized medicine approaches to the forefront of cardiovascular disease management. We describe how genomic data can resolve diagnostic uncertainty, support cascade screening, and inform treatment strategies. We discuss how genome-wide association studies have identified thousands of genetic variants associated with polygenic cardiovascular diseases, and how integrating these insights into polygenic risk scores can enhance personalized risk prediction beyond traditional clinical algorithms. We detail how pharmacogenomics approaches leverage genotype information to guide drug selection and mitigate adverse events. Finally, we present the paradigm-shifting approach of gene therapy, which holds the promise of being a curative intervention for cardiovascular conditions. 000160986 536__ $$9info:eu-repo/grantAgreement/ES/AEI/PID2021-128972OA-I00$$9info:eu-repo/grantAgreement/ES/AEI/PID2023-148975OB-I00$$9info:eu-repo/grantAgreement/ES/MICINN/CNS2023-143599$$9info:eu-repo/grantAgreement/ES/MICINN/RYC2021-031413-I 000160986 540__ $$9info:eu-repo/semantics/closedAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/ 000160986 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/acceptedVersion 000160986 700__ $$aYoung, William J. 000160986 700__ $$aNaderi, Hafiz 000160986 700__ $$aBurns, Richard 000160986 700__ $$0(orcid)0000-0003-4130-5866$$aRamírez, Julia$$uUniversidad de Zaragoza 000160986 700__ $$aBell, Christopher G. 000160986 700__ $$aMunroe, Patricia B. 000160986 7102_ $$15008$$2800$$aUniversidad de Zaragoza$$bDpto. Ingeniería Electrón.Com.$$cÁrea Teoría Señal y Comunicac. 000160986 773__ $$g45, 6 (2025), 866-881$$pArterioscler. thromb. vasc. biol.$$tArteriosclerosis, Thrombosis, and Vascular Biology$$x1079-5642 000160986 8564_ $$s1889949$$uhttps://zaguan.unizar.es/record/160986/files/texto_completo.pdf$$yPostprint 000160986 8564_ $$s2547494$$uhttps://zaguan.unizar.es/record/160986/files/texto_completo.jpg?subformat=icon$$xicon$$yPostprint 000160986 909CO $$ooai:zaguan.unizar.es:160986$$particulos$$pdriver 000160986 951__ $$a2025-10-17-14:18:58 000160986 980__ $$aARTICLE