000161007 001__ 161007 000161007 005__ 20251017144643.0 000161007 0247_ $$2doi$$a10.1002/chem.202500655 000161007 0248_ $$2sideral$$a144194 000161007 037__ $$aART-2025-144194 000161007 041__ $$aeng 000161007 100__ $$aPantoja-Romero, Wenndy 000161007 245__ $$aSolvent‐Free Process for Preparing Metal‐Organic Framework Composites Based on Carbon‐Based Quantum Dots and Their Derivatives as Drug Delivery Systems for Andrographolide 000161007 260__ $$c2025 000161007 5060_ $$aAccess copy available to the general public$$fUnrestricted 000161007 5203_ $$aAndrographolide (ADG) was conjugated with MIL-53(Al), ZIF-8, carbon-based quantum dots (CBQDs) and doped carbon-based quantum dots (D-CBQDs) using high-pressure (0.3 GPa) contact. This solvent-free approach is environmentally friendly, energy-efficient, and time-saving, resulting in ADG-MOFs-CBQDs/D-CBQDs with physical properties comparable to those produced by traditional liquid phase encapsulation. The resulting nanocomposites were characterized using SEM, XRD, TGA, FT-IR, and 1H NMR. The results indicate that ADG was partly encapsulated within the metal-organic framework (MOF) pores, while another portion was bound externally to CBQD/D-CBQDs, as evidenced by distinct drug signals in each analysis. This green synthesis approach simplifies the conjugation process. It significantly enhances the drug solubility, as indicated by changes in hydrophobicity observed via 1H NMR, surpassing the improvements achieved by ADG encapsulation within MOFs alone. Additionally, in preliminary tests, the materials exhibited significant cytotoxicity against PC3 cells compared to ADG (25.05 ± 0.06 µg/mL) after 48 hours of exposure. 000161007 536__ $$9info:eu-repo/grantAgreement/ES/DGA/T68-23R$$9info:eu-repo/grantAgreement/ES/MICINN/PID2022-138582OB-I00$$9info:eu-repo/grantAgreement/ES/MICIU/CEX2023-001286-S 000161007 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-nd$$uhttps://creativecommons.org/licenses/by-nc-nd/4.0/deed.es 000161007 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion 000161007 700__ $$aLavín-Flores, Alexis 000161007 700__ $$aMorell, Gerardo 000161007 700__ $$aMartínez-Ferrer, Magaly 000161007 700__ $$aWeiner, Brad R. 000161007 700__ $$0(orcid)0000-0003-1512-4500$$aCoronas, Joaquín$$uUniversidad de Zaragoza 000161007 7102_ $$15005$$2555$$aUniversidad de Zaragoza$$bDpto. Ing.Quím.Tecnol.Med.Amb.$$cÁrea Ingeniería Química 000161007 773__ $$g(2025), e202500655 [10 pp.]$$pChemistry (Weinh.)$$tChemistry - A European Journal$$x0947-6539 000161007 8564_ $$s3126891$$uhttps://zaguan.unizar.es/record/161007/files/texto_completo.pdf$$yVersión publicada 000161007 8564_ $$s2796901$$uhttps://zaguan.unizar.es/record/161007/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada 000161007 909CO $$ooai:zaguan.unizar.es:161007$$particulos$$pdriver 000161007 951__ $$a2025-10-17-14:32:58 000161007 980__ $$aARTICLE