161007 20251017144643.0 doi 10.1002/chem.202500655 sideral 144194 ART-2025-144194 eng Pantoja-Romero, Wenndy Solvent‐Free Process for Preparing Metal‐Organic Framework Composites Based on Carbon‐Based Quantum Dots and Their Derivatives as Drug Delivery Systems for Andrographolide 2025 Access copy available to the general public Unrestricted Andrographolide (ADG) was conjugated with MIL-53(Al), ZIF-8, carbon-based quantum dots (CBQDs) and doped carbon-based quantum dots (D-CBQDs) using high-pressure (0.3 GPa) contact. This solvent-free approach is environmentally friendly, energy-efficient, and time-saving, resulting in ADG-MOFs-CBQDs/D-CBQDs with physical properties comparable to those produced by traditional liquid phase encapsulation. The resulting nanocomposites were characterized using SEM, XRD, TGA, FT-IR, and 1H NMR. The results indicate that ADG was partly encapsulated within the metal-organic framework (MOF) pores, while another portion was bound externally to CBQD/D-CBQDs, as evidenced by distinct drug signals in each analysis. This green synthesis approach simplifies the conjugation process. It significantly enhances the drug solubility, as indicated by changes in hydrophobicity observed via 1H NMR, surpassing the improvements achieved by ADG encapsulation within MOFs alone. Additionally, in preliminary tests, the materials exhibited significant cytotoxicity against PC3 cells compared to ADG (25.05 ± 0.06 µg/mL) after 48 hours of exposure. info:eu-repo/grantAgreement/ES/DGA/T68-23R info:eu-repo/grantAgreement/ES/MICINN/PID2022-138582OB-I00 info:eu-repo/grantAgreement/ES/MICIU/CEX2023-001286-S info:eu-repo/semantics/openAccess by-nc-nd https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Lavín-Flores, Alexis Morell, Gerardo Martínez-Ferrer, Magaly Weiner, Brad R. Coronas, Joaquín Universidad de Zaragoza (orcid)0000-0003-1512-4500 5005 555 Universidad de Zaragoza Dpto. Ing.Quím.Tecnol.Med.Amb. Área Ingeniería Química (2025), e202500655 [10 pp.] Chemistry (Weinh.) Chemistry - A European Journal 0947-6539 3126891 http://zaguan.unizar.es/record/161007/files/texto_completo.pdf Versión publicada 2796901 http://zaguan.unizar.es/record/161007/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:161007 articulos driver 2025-10-17-14:32:58 ARTICLE