000161038 001__ 161038
000161038 005__ 20251017144556.0
000161038 0247_ $$2doi$$a10.1038/nature18618
000161038 0248_ $$2sideral$$a96145
000161038 037__ $$aART-2016-96145
000161038 041__ $$aeng
000161038 100__ $$0(orcid)0000-0002-4703-6620$$aLatorre-Pellicer, A.
000161038 245__ $$aMitochondrial and nuclear DNA matching shapes metabolism and healthy ageing
000161038 260__ $$c2016
000161038 5203_ $$aHuman mitochondrial DNA (mtDNA) shows extensive within-population sequence variability1. Many studies suggest that mtDNA variants may be associated with ageing or diseases2, 3, 4, although mechanistic evidence at the molecular level is lacking5, 6. Mitochondrial replacement has the potential to prevent transmission of disease-causing oocyte mtDNA. However, extension of this technology requires a comprehensive understanding of the physiological relevance of mtDNA sequence variability and its match with the nuclear-encoded mitochondrial genes. Studies in conplastic animals7, 8, 9 allow comparison of individuals with the same nuclear genome but different mtDNA variants, and have provided both supporting and refuting evidence that mtDNA variation influences organismal physiology. However, most of these studies did not confirm the conplastic status, focused on younger animals, and did not investigate the full range of physiological and phenotypic variability likely to be influenced by mitochondria. Here we systematically characterized conplastic mice throughout their lifespan using transcriptomic, proteomic, metabolomic, biochemical, physiological and phenotyping studies. We show that mtDNA haplotype profoundly influences mitochondrial proteostasis and reactive oxygen species generation, insulin signalling, obesity, and ageing parameters including telomere shortening and mitochondrial dysfunction, resulting in profound differences in health longevity between conplastic strains.
000161038 540__ $$9info:eu-repo/semantics/closedAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/
000161038 590__ $$a40.137$$b2016
000161038 591__ $$aMULTIDISCIPLINARY SCIENCES$$b1 / 63 = 0.016$$c2016$$dQ1$$eT1
000161038 592__ $$a18.388$$b2016
000161038 593__ $$aMultidisciplinary$$c2016$$dQ1
000161038 655_4 $$ainfo:eu-repo/semantics/other$$vinfo:eu-repo/semantics/publishedVersion
000161038 700__ $$0(orcid)0000-0002-6600-1618$$aMoreno-Loshuertos, R.$$uUniversidad de Zaragoza
000161038 700__ $$aLechuga-Vieco, A.
000161038 700__ $$aSánchez-Cabo, F.
000161038 700__ $$aTorroja, C.
000161038 700__ $$aAcín-Pérez, R.
000161038 700__ $$aCalvo, E.
000161038 700__ $$aAix, E.
000161038 700__ $$aGonzález-Guerra, A.
000161038 700__ $$aLogan, A.
000161038 700__ $$aBernad-Miana, M.
000161038 700__ $$aRomanos, E.
000161038 700__ $$aCruz, R.
000161038 700__ $$aCogliati, S.
000161038 700__ $$aSobrino, B.
000161038 700__ $$aCarracedo, Á.
000161038 700__ $$0(orcid)0000-0002-8705-2799$$aPérez-Martos, A.
000161038 700__ $$0(orcid)0000-0001-8971-7355$$aFernández-Silva, P.$$uUniversidad de Zaragoza
000161038 700__ $$aRuíz-Cabello, J.
000161038 700__ $$aMurphy, M.P.
000161038 700__ $$aFlores, I.
000161038 700__ $$aVázquez, J.
000161038 700__ $$0(orcid)0000-0002-4931-6730$$aEnríquez, J.A.$$uUniversidad de Zaragoza
000161038 7102_ $$11002$$2060$$aUniversidad de Zaragoza$$bDpto. Bioq.Biolog.Mol. Celular$$cÁrea Bioquímica y Biolog.Mole.
000161038 773__ $$g535 (2016), 561-565$$pNature$$tNature$$x0028-0836
000161038 8564_ $$s5784675$$uhttps://zaguan.unizar.es/record/161038/files/texto_completo.pdf$$yVersión publicada
000161038 8564_ $$s4061440$$uhttps://zaguan.unizar.es/record/161038/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000161038 909CO $$ooai:zaguan.unizar.es:161038$$particulos$$pdriver
000161038 951__ $$a2025-10-17-14:13:18
000161038 980__ $$aARTICLE