000161087 001__ 161087
000161087 005__ 20251017144627.0
000161087 0247_ $$2doi$$a10.3390/molecules30102240
000161087 0248_ $$2sideral$$a144249
000161087 037__ $$aART-2025-144249
000161087 041__ $$aeng
000161087 100__ $$aReyes-Vaquero, Lorena
000161087 245__ $$aBiological Activity Evaluation Against Fusarium oxysporum, Fusarium circinatum, and Meloidogyne incognita of Bioactives-Enriched Extracts of Ruta graveolens L.
000161087 260__ $$c2025
000161087 5060_ $$aAccess copy available to the general public$$fUnrestricted
000161087 5203_ $$aRuta graveolens L. has been described as possessing antifungal and nematicidal activity. Among the bioactive compounds present in this plant, alkaloids and furanocoumarins have attracted considerable attention. The aim of this study was to evaluate the in vitro biological activity of extracts from rue enriched in bioactive compounds against Fusarium oxysporum, F. circinatum, and Meloidogyne incognita, and to correlate the chemical profile of the extracts with their biological activities. Six extracts with contrasting chemical profiles, obtained by pressurized liquid extraction and supercritical fluid extraction using green solvents, were selected for biological evaluation. The highest F. oxysporum growth inhibition was achieved with the extracts enriched in fatty acids and furanocoumarins at concentrations of 4, 8, and 16 mg/mL, while for F. circinatum, the highest growth inhibition was obtained using the extract enriched in terpenes at 16 mg/mL; moreover, the six extracts evaluated caused mortality in M. incognita. Therefore, enriched extracts of R. graveolens might be considered as an alternative for pathogen control on economically important crops such as potatoes, tomatoes, and onions, among others. Correlations between biological activities and chemical compositions suggest the importance of fatty acids against F. oxysporum, fatty acids and terpenes against F. circinatum, and alkaloids, coumarins, and furanocoumarins for M. incognita.
000161087 536__ $$9info:eu-repo/grantAgreement/ES/MCIU/IJC-2018-037830-I$$9info:eu-repo/grantAgreement/ES/MINECO/Juan de La Cierva-Formación-FJCI-2016-30902
000161087 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttps://creativecommons.org/licenses/by/4.0/deed.es
000161087 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000161087 700__ $$aIbáñez, Elena
000161087 700__ $$aSanz-Alférez, Soledad
000161087 700__ $$aNombela, Gloria
000161087 700__ $$aDel Villar-Martínez, Alma Angélica
000161087 700__ $$0(orcid)0000-0002-5904-8506$$aBueno, Mónica$$uUniversidad de Zaragoza
000161087 7102_ $$12009$$2750$$aUniversidad de Zaragoza$$bDpto. Química Analítica$$cÁrea Química Analítica
000161087 773__ $$g30, 10 (2025), 2240 [15 pp.]$$pMolecules (Basel, Online)$$tMolecules$$x1420-3049
000161087 8564_ $$s1024748$$uhttps://zaguan.unizar.es/record/161087/files/texto_completo.pdf$$yVersión publicada
000161087 8564_ $$s2648499$$uhttps://zaguan.unizar.es/record/161087/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000161087 909CO $$ooai:zaguan.unizar.es:161087$$particulos$$pdriver
000161087 951__ $$a2025-10-17-14:24:34
000161087 980__ $$aARTICLE