161094 20251017144632.0 doi 10.1113/JP288197 sideral 144292 ART-2025-144292 eng Bueno-Palomeque, Freddy L. Electrophysiological characterization of pre‐adolescents born with intrauterine growth restriction: insights from clinical and computational data 2025 Access copy available to the general public Unrestricted Anatomical changes associated with intra-uterine growth restriction (IUGR) have been observed in different age groups and linked to cardiovascular complications. This study analysed the electrocardiogram (ECG) in pre-adolescents with severe IUGR, comparing QRS complex and T-wave biomarkers with controls. Computer simulations explored links between anatomical re-modelling and ECG biomarkers, providing insights into the potential cardiovascular risk associated with IUGR-induced re-modelling. Clinical recordings were analysed using principal component analysis (PCA) to compute spatially transformed leads, enhancing QRS complex and T-wave delineation for depolarization and repolarization assessment. Transformed leads analysis revealed a 4-ms increase in QRS complex duration (QRS ) and a 2-ms increase in the T peak-to-end interval (T ) in IUGR subjects compared to controls. We conducted electrophysiological in silico simulations using anatomical models based on clinical IUGR data. These models, derived from a reference control, incorporated key geometric changes associated with IUGR, the apex-base length, basal diameter, wall thickness () and ventricular tissue volume, to assess their impact on depolarization and repolarization intervals. In silico PCA leads showed increased QRS , QRS amplitude and T in globular models, consistent with clinical data. Despite the QRS increase, the QT interval increases but is not linearly related to the change. These findings suggest that cardiac re-modelling primarily influences the depolarization cycle, notably QRS , while repolarization intervals increase but are not directly related to the increase. The study highlights the impact of geometric and volumetric changes in IUGR-related cardiac re-modelling, also emphasizing the need for further research on electrophysiological re-modelling and its effects on cardiac function. info:eu-repo/grantAgreement/ES/AEI/PID2021-128972OA-I00 info:eu-repo/grantAgreement/ES/DGA/T39-23R info:eu-repo/grantAgreement/ES/MICINN/CNS2022-135899 info:eu-repo/grantAgreement/ES/MICINN/PID2022-140556OB-I00 info:eu-repo/grantAgreement/ES/MICINN/RYC2019-027420-I info:eu-repo/grantAgreement/EUR/MICINN/TED2021-130459B-I00 info:eu-repo/semantics/openAccess by-nc https://creativecommons.org/licenses/by-nc/4.0/deed.es info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Zacur, Ernesto Pueyo, Esther Universidad de Zaragoza (orcid)0000-0002-1960-407X Crispi, Fàtima Laguna, Pablo Universidad de Zaragoza (orcid)0000-0003-3434-9254 Mincholé, Ana Universidad de Zaragoza (orcid)0000-0003-3183-4107 5008 800 Universidad de Zaragoza Dpto. Ingeniería Electrón.Com. Área Teoría Señal y Comunicac. (2025), [20 pp.] J. physiol. JOURNAL OF PHYSIOLOGY-LONDON 0022-3751 2684106 http://zaguan.unizar.es/record/161094/files/texto_completo.pdf Versión publicada 2284345 http://zaguan.unizar.es/record/161094/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:161094 articulos driver 2025-10-17-14:26:56 ARTICLE