000161108 001__ 161108
000161108 005__ 20251219150010.0
000161108 0247_ $$2doi$$a10.1126/science.1230381
000161108 0248_ $$2sideral$$a82712
000161108 037__ $$aART-2013-82712
000161108 041__ $$aeng
000161108 100__ $$aLapuente-Brun, E.
000161108 245__ $$aSupercomplex assembly determines electron flux in the mitochondrial electron transport chain
000161108 260__ $$c2013
000161108 5203_ $$aThe textbook description of mitochondrial respiratory complexes (RCs) views them as free-moving entities linked by the mobile carriers coenzyme Q (CoQ) and cytochrome c (cyt c). This model (known as the fluid model) is challenged by the proposal that all RCs except complex II can associate in supercomplexes (SCs). The proposed SCs are the respirasome (complexes I, III, and IV), complexes I and III, and complexes III and IV. The role of SCs is unclear, and their existence is debated. By genetic modulation of interactions between complexes I and III and III and IV, we show that these associations define dedicated CoQ and cyt c pools and that SC assembly is dynamic and organizes electron flux to optimize the use of available substrates.
000161108 540__ $$9info:eu-repo/semantics/closedAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/
000161108 590__ $$a31.477$$b2013
000161108 591__ $$aMULTIDISCIPLINARY SCIENCES$$b2 / 56 = 0.036$$c2013$$dQ1$$eT1
000161108 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000161108 700__ $$0(orcid)0000-0002-6600-1618$$aMoreno-Loshuertos, R.$$uUniversidad de Zaragoza
000161108 700__ $$aAcín-Pérez, R.
000161108 700__ $$0(orcid)0000-0002-4703-6620$$aLatorre-Pellicer, A.
000161108 700__ $$aColas, C.
000161108 700__ $$aBalsa, E.
000161108 700__ $$aPerales-Clemente, E.
000161108 700__ $$aQuirós, P.M.
000161108 700__ $$aCalvo, E.
000161108 700__ $$aRodríguez-Hernández, M.A.
000161108 700__ $$aNavas, P.
000161108 700__ $$aCruz, R.
000161108 700__ $$aCarracedo, Á.
000161108 700__ $$aLópez-Otín, C.
000161108 700__ $$aPérez-Martos, A.
000161108 700__ $$0(orcid)0000-0001-8971-7355$$aFernández-Silva, P.$$uUniversidad de Zaragoza
000161108 700__ $$0(orcid)0000-0002-2469-142X$$aFernández-Vizarra, E.
000161108 700__ $$aEnríquez, J.A.
000161108 7102_ $$11002$$2060$$aUniversidad de Zaragoza$$bDpto. Bioq.Biolog.Mol. Celular$$cÁrea Bioquímica y Biolog.Mole.
000161108 773__ $$g340, 6140 (2013), 1567-1570$$pSci.$$tScience$$x0036-8075
000161108 8564_ $$s1155603$$uhttps://zaguan.unizar.es/record/161108/files/texto_completo.pdf$$yVersión publicada
000161108 8564_ $$s4253694$$uhttps://zaguan.unizar.es/record/161108/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000161108 909CO $$ooai:zaguan.unizar.es:161108$$particulos$$pdriver
000161108 951__ $$a2025-12-19-14:58:13
000161108 980__ $$aARTICLE