161108 20251219150010.0 doi 10.1126/science.1230381 sideral 82712 ART-2013-82712 eng Lapuente-Brun, E. Supercomplex assembly determines electron flux in the mitochondrial electron transport chain 2013 The textbook description of mitochondrial respiratory complexes (RCs) views them as free-moving entities linked by the mobile carriers coenzyme Q (CoQ) and cytochrome c (cyt c). This model (known as the fluid model) is challenged by the proposal that all RCs except complex II can associate in supercomplexes (SCs). The proposed SCs are the respirasome (complexes I, III, and IV), complexes I and III, and complexes III and IV. The role of SCs is unclear, and their existence is debated. By genetic modulation of interactions between complexes I and III and III and IV, we show that these associations define dedicated CoQ and cyt c pools and that SC assembly is dynamic and organizes electron flux to optimize the use of available substrates. info:eu-repo/semantics/closedAccess All rights reserved http://www.europeana.eu/rights/rr-f/ 31.477 2013 MULTIDISCIPLINARY SCIENCES 2 / 56 = 0.036 2013 Q1 T1 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Moreno-Loshuertos, R. Universidad de Zaragoza (orcid)0000-0002-6600-1618 Acín-Pérez, R. Latorre-Pellicer, A. (orcid)0000-0002-4703-6620 Colas, C. Balsa, E. Perales-Clemente, E. Quirós, P.M. Calvo, E. Rodríguez-Hernández, M.A. Navas, P. Cruz, R. Carracedo, Á. López-Otín, C. Pérez-Martos, A. Fernández-Silva, P. Universidad de Zaragoza (orcid)0000-0001-8971-7355 Fernández-Vizarra, E. (orcid)0000-0002-2469-142X Enríquez, J.A. 1002 060 Universidad de Zaragoza Dpto. Bioq.Biolog.Mol. Celular Área Bioquímica y Biolog.Mole. 340, 6140 (2013), 1567-1570 Sci. Science 0036-8075 1155603 http://zaguan.unizar.es/record/161108/files/texto_completo.pdf Versión publicada 4253694 http://zaguan.unizar.es/record/161108/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:161108 articulos driver 2025-12-19-14:58:13 ARTICLE