000161112 001__ 161112
000161112 005__ 20251017144643.0
000161112 0247_ $$2doi$$a10.1021/acsabm.5c00233
000161112 0248_ $$2sideral$$a144216
000161112 037__ $$aART-2025-144216
000161112 041__ $$aeng
000161112 100__ $$aFernández-Méndez, Laura
000161112 245__ $$aNIR-II Photoresponsive Magnetoliposomes for Remote-Controlled Release and Magnetic Resonance Imaging
000161112 260__ $$c2025
000161112 5060_ $$aAccess copy available to the general public$$fUnrestricted
000161112 5203_ $$aMagnetic nanoparticles, especially iron oxide nano-particles, have become versatile and widely used tools in nanomedicinedue to their unique magnetic properties, biocompatibility, and tunablefunctionality. Liposomes have further enhanced the potential of ironoxide nanoparticles by serving as effective nanocarriers with advantagessuch as drug coencapsulation and enhanced molecular imagingproperties. In this study, we present magnetoliposomes composed ofultrasmall free-floating iron oxide nanoparticles inside liposomes (LP-IONPs) and thermoresponsive phospholipids, which were designed asdual T2-T1 magnetic resonance imaging (MRI) contrast agents forimage-guided liposome degradation and infrared light-responsivenanocarriers in the second biological window for remote-controlleddrug delivery. We demonstrated a dynamic shift from T2 to T1 MRIcontrast during intracellular degradation of LP-IONPs, along with successful light-activated drug release in cancer cells.Biodistribution studies using MRI and histological analysis confirmed their potential for in vivo applications. These results highlightthe potential of LP-IONPs as image-guided and remote-controlled drug delivery systems.
000161112 536__ $$9info:eu-repo/grantAgreement/ES/AEI/AEI PID2021-123238OB-I00$$9info:eu-repo/grantAgreement/ES/DGA/E15-23R$$9info:eu-repo/grantAgreement/ES/MCIN/PID2019-106139RA-100$$9info:eu-repo/grantAgreement/ES/MICINN/CNS2023-143944$$9info:eu-repo/grantAgreement/ES/MICINN/CNS2023-144321$$9info:eu-repo/grantAgreement/ES/MICINN/RYC2020-030241-I
000161112 540__ $$9info:eu-repo/semantics/embargoedAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/
000161112 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/acceptedVersion
000161112 700__ $$0(orcid)0000-0002-0970-1917$$aFernández-Afonso, Yilian
000161112 700__ $$aMartínez-Vicente, Pablo$$uUniversidad de Zaragoza
000161112 700__ $$aUrkola-Arsuaga, Ainhize
000161112 700__ $$aMiranda-Pérez de Alejo, Claudia
000161112 700__ $$aL. de la Pisa, Irati
000161112 700__ $$aPlaza-García, Sandra
000161112 700__ $$aRuíz-Cabello, Jesús
000161112 700__ $$aRamos-Cabrer, Pedro
000161112 700__ $$0(orcid)0000-0003-2366-3598$$aGutiérrez, Lucía
000161112 700__ $$aCarregal-Romero, Susana
000161112 7102_ $$11003$$2027$$aUniversidad de Zaragoza$$bDpto. Anatom.Histolog.Humanas$$cArea Anatom.Embriol.Humana
000161112 773__ $$g(2025), [15 pp.]$$pACS appl. bio mater.$$tACS Applied Bio Materials$$x2576-6422
000161112 8564_ $$s1735894$$uhttps://zaguan.unizar.es/record/161112/files/texto_completo.pdf$$yPostprint$$zinfo:eu-repo/date/embargoEnd/2026-05-13
000161112 8564_ $$s1142783$$uhttps://zaguan.unizar.es/record/161112/files/texto_completo.jpg?subformat=icon$$xicon$$yPostprint$$zinfo:eu-repo/date/embargoEnd/2026-05-13
000161112 909CO $$ooai:zaguan.unizar.es:161112$$particulos$$pdriver
000161112 951__ $$a2025-10-17-14:32:58
000161112 980__ $$aARTICLE