doi:10.1021/acsabm.5c00233engFernández-Méndez, LauraFernández-Afonso, YilianMartínez-Vicente, PabloUrkola-Arsuaga, AinhizeMiranda-Pérez de Alejo, ClaudiaL. de la Pisa, IratiPlaza-García, SandraRuíz-Cabello, JesúsRamos-Cabrer, PedroGutiérrez, LucíaCarregal-Romero, SusanaNIR-II Photoresponsive Magnetoliposomes for Remote-Controlled Release and Magnetic Resonance ImagingART-2025-144216Magnetic nanoparticles, especially iron oxide nano-particles, have become versatile and widely used tools in nanomedicinedue to their unique magnetic properties, biocompatibility, and tunablefunctionality. Liposomes have further enhanced the potential of ironoxide nanoparticles by serving as effective nanocarriers with advantagessuch as drug coencapsulation and enhanced molecular imagingproperties. In this study, we present magnetoliposomes composed ofultrasmall free-floating iron oxide nanoparticles inside liposomes (LP-IONPs) and thermoresponsive phospholipids, which were designed asdual T2-T1 magnetic resonance imaging (MRI) contrast agents forimage-guided liposome degradation and infrared light-responsivenanocarriers in the second biological window for remote-controlleddrug delivery. We demonstrated a dynamic shift from T2 to T1 MRIcontrast during intracellular degradation of LP-IONPs, along with successful light-activated drug release in cancer cells.Biodistribution studies using MRI and histological analysis confirmed their potential for in vivo applications. These results highlightthe potential of LP-IONPs as image-guided and remote-controlled drug delivery systems.2025http://zaguan.unizar.es/record/16111210.1021/acsabm.5c00233http://zaguan.unizar.es/record/161112oai:zaguan.unizar.es:161112info:eu-repo/grantAgreement/ES/AEI/AEI PID2021-123238OB-I00info:eu-repo/grantAgreement/ES/DGA/E15-23Rinfo:eu-repo/grantAgreement/ES/MCIN/PID2019-106139RA-100info:eu-repo/grantAgreement/ES/MICINN/CNS2023-143944info:eu-repo/grantAgreement/ES/MICINN/CNS2023-144321info:eu-repo/grantAgreement/ES/MICINN/RYC2020-030241-IACS Applied Bio Materials (2025), [15 pp.]All rights reservedhttp://www.europeana.eu/rights/rr-f/info:eu-repo/semantics/embargoedAccess