161112 20251017144643.0 doi 10.1021/acsabm.5c00233 sideral 144216 ART-2025-144216 eng Fernández-Méndez, Laura NIR-II Photoresponsive Magnetoliposomes for Remote-Controlled Release and Magnetic Resonance Imaging 2025 Access copy available to the general public Unrestricted Magnetic nanoparticles, especially iron oxide nano-particles, have become versatile and widely used tools in nanomedicinedue to their unique magnetic properties, biocompatibility, and tunablefunctionality. Liposomes have further enhanced the potential of ironoxide nanoparticles by serving as effective nanocarriers with advantagessuch as drug coencapsulation and enhanced molecular imagingproperties. In this study, we present magnetoliposomes composed ofultrasmall free-floating iron oxide nanoparticles inside liposomes (LP-IONPs) and thermoresponsive phospholipids, which were designed asdual T2-T1 magnetic resonance imaging (MRI) contrast agents forimage-guided liposome degradation and infrared light-responsivenanocarriers in the second biological window for remote-controlleddrug delivery. We demonstrated a dynamic shift from T2 to T1 MRIcontrast during intracellular degradation of LP-IONPs, along with successful light-activated drug release in cancer cells.Biodistribution studies using MRI and histological analysis confirmed their potential for in vivo applications. These results highlightthe potential of LP-IONPs as image-guided and remote-controlled drug delivery systems. info:eu-repo/grantAgreement/ES/AEI/AEI PID2021-123238OB-I00 info:eu-repo/grantAgreement/ES/DGA/E15-23R info:eu-repo/grantAgreement/ES/MCIN/PID2019-106139RA-100 info:eu-repo/grantAgreement/ES/MICINN/CNS2023-143944 info:eu-repo/grantAgreement/ES/MICINN/CNS2023-144321 info:eu-repo/grantAgreement/ES/MICINN/RYC2020-030241-I info:eu-repo/semantics/embargoedAccess All rights reserved http://www.europeana.eu/rights/rr-f/ info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion Fernández-Afonso, Yilian (orcid)0000-0002-0970-1917 Martínez-Vicente, Pablo Universidad de Zaragoza Urkola-Arsuaga, Ainhize Miranda-Pérez de Alejo, Claudia L. de la Pisa, Irati Plaza-García, Sandra Ruíz-Cabello, Jesús Ramos-Cabrer, Pedro Gutiérrez, Lucía (orcid)0000-0003-2366-3598 Carregal-Romero, Susana 1003 027 Universidad de Zaragoza Dpto. Anatom.Histolog.Humanas Area Anatom.Embriol.Humana (2025), [15 pp.] ACS appl. bio mater. ACS Applied Bio Materials 2576-6422 1735894 http://zaguan.unizar.es/record/161112/files/texto_completo.pdf Postprint info:eu-repo/date/embargoEnd/2026-05-13 1142783 http://zaguan.unizar.es/record/161112/files/texto_completo.jpg?subformat=icon icon Postprint info:eu-repo/date/embargoEnd/2026-05-13 oai:zaguan.unizar.es:161112 articulos driver 2025-10-17-14:32:58 ARTICLE