000161121 001__ 161121
000161121 005__ 20260418110659.0
000161121 0247_ $$2doi$$a10.1111/all.16578
000161121 0248_ $$2sideral$$a144246
000161121 037__ $$aART-2025-144246
000161121 041__ $$aeng
000161121 100__ $$aSanz-Rubio, D.
000161121 245__ $$aLinking Exosomal MicroRNA Signatures in Sputum and Peripheral Blood to Inflammatory Endotypes in Severe Asthma
000161121 260__ $$c2025
000161121 5060_ $$aAccess copy available to the general public$$fUnrestricted
000161121 5203_ $$aThis study is the first to identify and validate distinct exosomal miRNA signatures in both plasma and induced sputum that differentiate T2-high and T2-low endotypes in severe asthma. By integrating miRNA expression with clinical parameters, we developed predictive models with high discriminatory power, highlighting the potential of these miRNAs as non-invasive biomarkers. These findings offer new insights into the molecular basis of asthma endotypes and support a precision medicine approach. In this revised version, guided by the reviewers’ comments, we have improved the clarity of our manuscript by including a new version of Figure 1 with adjusted graphs and greater consistency across panels. We have also added methodological clarifications to enhance the understanding of the experimental workflow, such as the selection criteria for the miRNAs included in the validation step. Additionally, we have completed the clinical data tables to reflect other relevant aspects, such as neutrophil counts and oral corticosteroid use. We are grateful for the opportunity to resubmit this work and for the reviewers’ efforts, which have helped us strengthen several aspects of our manuscript.
000161121 536__ $$9info:eu-repo/grantAgreement/ES/DGA/B22-23R$$9info:eu-repo/grantAgreement/ES/DGA-CUS/1638-2022$$9info:eu-repo/grantAgreement/ES/ISCIII CD22-00033
000161121 540__ $$9info:eu-repo/semantics/openAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/
000161121 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/acceptedVersion
000161121 700__ $$aVera, E.
000161121 700__ $$aRodríguez-Sanz, J.
000161121 700__ $$aCubero, J.
000161121 700__ $$aLangarita, R.
000161121 700__ $$aAguado, M.
000161121 700__ $$aPastor, L.
000161121 700__ $$aMartín, L.
000161121 700__ $$aMarín-Oto, M.
000161121 700__ $$0(orcid)0000-0002-1075-8267$$aRemacha, A. R.
000161121 700__ $$aRuiz, M.
000161121 700__ $$aGil, V.
000161121 700__ $$aDomingo, J. A.
000161121 700__ $$aCarretero, J. A.
000161121 700__ $$aMarín, J. M.
000161121 773__ $$g80, 7 (2025), 2073-2076$$pAllergy$$tAllergy: European Journal of Allergy and Clinical Immunology$$x0105-4538
000161121 8564_ $$s1981859$$uhttps://zaguan.unizar.es/record/161121/files/texto_completo.pdf$$yVersión publicada
000161121 8564_ $$s1234704$$uhttps://zaguan.unizar.es/record/161121/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000161121 909CO $$ooai:zaguan.unizar.es:161121$$particulos$$pdriver
000161121 951__ $$a2026-04-18-11:05:08
000161121 980__ $$aARTICLE