161121 20260418110659.0 doi 10.1111/all.16578 sideral 144246 ART-2025-144246 eng Sanz-Rubio, D. Linking Exosomal MicroRNA Signatures in Sputum and Peripheral Blood to Inflammatory Endotypes in Severe Asthma 2025 Access copy available to the general public Unrestricted This study is the first to identify and validate distinct exosomal miRNA signatures in both plasma and induced sputum that differentiate T2-high and T2-low endotypes in severe asthma. By integrating miRNA expression with clinical parameters, we developed predictive models with high discriminatory power, highlighting the potential of these miRNAs as non-invasive biomarkers. These findings offer new insights into the molecular basis of asthma endotypes and support a precision medicine approach. In this revised version, guided by the reviewers’ comments, we have improved the clarity of our manuscript by including a new version of Figure 1 with adjusted graphs and greater consistency across panels. We have also added methodological clarifications to enhance the understanding of the experimental workflow, such as the selection criteria for the miRNAs included in the validation step. Additionally, we have completed the clinical data tables to reflect other relevant aspects, such as neutrophil counts and oral corticosteroid use. We are grateful for the opportunity to resubmit this work and for the reviewers’ efforts, which have helped us strengthen several aspects of our manuscript. info:eu-repo/grantAgreement/ES/DGA/B22-23R info:eu-repo/grantAgreement/ES/DGA-CUS/1638-2022 info:eu-repo/grantAgreement/ES/ISCIII CD22-00033 info:eu-repo/semantics/openAccess All rights reserved http://www.europeana.eu/rights/rr-f/ info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion Vera, E. Rodríguez-Sanz, J. Cubero, J. Langarita, R. Aguado, M. Pastor, L. Martín, L. Marín-Oto, M. Remacha, A. R. (orcid)0000-0002-1075-8267 Ruiz, M. Gil, V. Domingo, J. A. Carretero, J. A. Marín, J. M. 80, 7 (2025), 2073-2076 Allergy Allergy: European Journal of Allergy and Clinical Immunology 0105-4538 1981859 http://zaguan.unizar.es/record/161121/files/texto_completo.pdf Versión publicada 1234704 http://zaguan.unizar.es/record/161121/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:161121 articulos driver 2026-04-18-11:05:08 ARTICLE