000161665 001__ 161665
000161665 005__ 20251017144605.0
000161665 0247_ $$2doi$$a10.1021/acssuschemeng.5c00269
000161665 0248_ $$2sideral$$a144312
000161665 037__ $$aART-2025-144312
000161665 041__ $$aeng
000161665 100__ $$aGracia-Barberán, Sara
000161665 245__ $$aEco-Friendly Solvents for Bioactives: Solubilization of Hydroxycinnamic Acids in Glycerol-Derived Ethers
000161665 260__ $$c2025
000161665 5060_ $$aAccess copy available to the general public$$fUnrestricted
000161665 5203_ $$aHydroxycinnamic acids, such as coumaric, ferulic, and caffeic acids, stand out for their pharmacological and cosmetic applications due to their bioactive properties. However, their low solubility in water and conventional solvents can be considered a drawback for their effective utilization. This study investigates the solubility of these acids in renewable glycerol-derived ethers, which exhibit good ecotoxicological profiles and tunable physicochemical properties. Experimental solubility data revealed that monoethers and diethers with shorter alkyl chains significantly enhance the solubility of the studied hydroxycinnamic acids. The findings were further corroborated by COSMO-RS modeling, highlighting the importance of both hydrogen-bond donor capacity and polarity-polarizability in solubility enhancement. Hydrotropic effects of glycerol ethers in water were also experimentally demonstrated, indicating their potential in pharmaceutical and industrial formulations. These results underscore the efficacy of glycerol-derived solvents as sustainable alternatives for solubilizing hydroxycinnamic acids, paving the way for greener and more efficient applications.
000161665 536__ $$9info:eu-repo/grantAgreement/ES/DGA/E37-23R$$9info:eu-repo/grantAgreement/ES/DGA/E39-23R$$9info:eu-repo/grantAgreement/ES/MINECO/PID2021-125762NB-I00
000161665 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttps://creativecommons.org/licenses/by/4.0/deed.es
000161665 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000161665 700__ $$aLanau, María
000161665 700__ $$0(orcid)0000-0002-3256-2089$$aLeal-Duaso, Alejandro
000161665 700__ $$0(orcid)0000-0001-8105-2432$$aLópez Ram de Viu, Pilar$$uUniversidad de Zaragoza
000161665 700__ $$0(orcid)0000-0001-9379-8047$$aMainar, Ana M.$$uUniversidad de Zaragoza
000161665 700__ $$0(orcid)0000-0003-1570-4257$$aMayoral, José A.$$uUniversidad de Zaragoza
000161665 700__ $$0(orcid)0000-0002-2676-8814$$aPires, Elísabet$$uUniversidad de Zaragoza
000161665 7102_ $$12013$$2765$$aUniversidad de Zaragoza$$bDpto. Química Orgánica$$cÁrea Química Orgánica
000161665 7102_ $$12012$$2755$$aUniversidad de Zaragoza$$bDpto. Química Física$$cÁrea Química Física
000161665 773__ $$g(2025), [11 pp.]$$pACS sustain. chem. & eng.$$tACS Sustainable Chemistry and Engineering$$x2168-0485
000161665 8564_ $$s4378373$$uhttps://zaguan.unizar.es/record/161665/files/texto_completo.pdf$$yVersión publicada
000161665 8564_ $$s3060210$$uhttps://zaguan.unizar.es/record/161665/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000161665 909CO $$ooai:zaguan.unizar.es:161665$$particulos$$pdriver
000161665 951__ $$a2025-10-17-14:15:07
000161665 980__ $$aARTICLE