161665 20251017144605.0 doi 10.1021/acssuschemeng.5c00269 sideral 144312 ART-2025-144312 eng Gracia-Barberán, Sara Eco-Friendly Solvents for Bioactives: Solubilization of Hydroxycinnamic Acids in Glycerol-Derived Ethers 2025 Access copy available to the general public Unrestricted Hydroxycinnamic acids, such as coumaric, ferulic, and caffeic acids, stand out for their pharmacological and cosmetic applications due to their bioactive properties. However, their low solubility in water and conventional solvents can be considered a drawback for their effective utilization. This study investigates the solubility of these acids in renewable glycerol-derived ethers, which exhibit good ecotoxicological profiles and tunable physicochemical properties. Experimental solubility data revealed that monoethers and diethers with shorter alkyl chains significantly enhance the solubility of the studied hydroxycinnamic acids. The findings were further corroborated by COSMO-RS modeling, highlighting the importance of both hydrogen-bond donor capacity and polarity-polarizability in solubility enhancement. Hydrotropic effects of glycerol ethers in water were also experimentally demonstrated, indicating their potential in pharmaceutical and industrial formulations. These results underscore the efficacy of glycerol-derived solvents as sustainable alternatives for solubilizing hydroxycinnamic acids, paving the way for greener and more efficient applications. info:eu-repo/grantAgreement/ES/DGA/E37-23R info:eu-repo/grantAgreement/ES/DGA/E39-23R info:eu-repo/grantAgreement/ES/MINECO/PID2021-125762NB-I00 info:eu-repo/semantics/openAccess by https://creativecommons.org/licenses/by/4.0/deed.es info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Lanau, María Leal-Duaso, Alejandro (orcid)0000-0002-3256-2089 López Ram de Viu, Pilar Universidad de Zaragoza (orcid)0000-0001-8105-2432 Mainar, Ana M. Universidad de Zaragoza (orcid)0000-0001-9379-8047 Mayoral, José A. Universidad de Zaragoza (orcid)0000-0003-1570-4257 Pires, Elísabet Universidad de Zaragoza (orcid)0000-0002-2676-8814 2013 765 Universidad de Zaragoza Dpto. Química Orgánica Área Química Orgánica 2012 755 Universidad de Zaragoza Dpto. Química Física Área Química Física (2025), [11 pp.] ACS sustain. chem. & eng. ACS Sustainable Chemistry and Engineering 2168-0485 4378373 http://zaguan.unizar.es/record/161665/files/texto_completo.pdf Versión publicada 3060210 http://zaguan.unizar.es/record/161665/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:161665 articulos driver 2025-10-17-14:15:07 ARTICLE