000161702 001__ 161702
000161702 005__ 20251017144605.0
000161702 0247_ $$2doi$$a10.3390/nu17111869
000161702 0248_ $$2sideral$$a144359
000161702 037__ $$aART-2025-144359
000161702 041__ $$aeng
000161702 100__ $$aAkritidis, Jordan
000161702 245__ $$aPhthalate Metabolites and Their Relationship with Abdominal and General Obesity: Evidence from the Aragon Workers’ Health Study (AWHS)
000161702 260__ $$c2025
000161702 5060_ $$aAccess copy available to the general public$$fUnrestricted
000161702 5203_ $$aBackground/Objectives: Phthalates are endocrine-disrupting chemicals that are commonly used in plastic consumer products and food packaging, with growing evidence suggesting that they have a potential role in obesity. This study aimed to investigate the association between urinary concentrations of phthalate metabolites and both general and abdominal obesity among adult males in Spain. Methods: We analysed data from 1124 male participants of the Aragon Workers’ Health Study (AWHS) collected between 2011 and 2014 in Zaragoza, Spain. Eleven urinary phthalate metabolites were measured and adjusted for creatinine levels. Multivariate logistic regression models were used to evaluate associations between phthalate exposure and general and abdominal obesity, controlling for dietary and lifestyle factors. Dose–response relationships were explored using restricted cubic spline models. Results: Higher urinary concentrations of di(2-ethylhexyl) phthalate (∑DEHP) and two of its metabolites—mono-(2-ethyl-5-oxohexyl) phthalate (MEOHP) and mono-(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP)—were significantly associated with general obesity. The adjusted odds ratios were: ∑DEHP [OR = 1.26; 95% CI: 1.01, 1.58], MEOHP [OR = 1.24; 95% CI: 1.00, 1.53], and MEHHP [OR = 1.26; 95% CI: 1.03, 1.55]. In contrast, mono-isobutyl phthalate (MiBP) was inversely associated with abdominal obesity [OR = 0.73; 95% CI: 0.57, 0.93]. Conclusions: These findings suggest a positive association between exposure to DEHP and its metabolites and general obesity. This highlights the potential importance of environmental exposures as modifiable factors in obesity prevention and supports the need for further investigation in nutritional and public health contexts.
000161702 536__ $$9info:eu-repo/grantAgreement/ES/ISCIII/PI20-144$$9info:eu-repo/grantAgreement/ES/ISCIII/PI23-240
000161702 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttps://creativecommons.org/licenses/by/4.0/deed.es
000161702 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000161702 700__ $$aMérida, Diana María
000161702 700__ $$aTorrijo-Belanche, Carolina$$uUniversidad de Zaragoza
000161702 700__ $$0(orcid)0000-0003-0604-5042$$aMoreno-Franco, Belén$$uUniversidad de Zaragoza
000161702 700__ $$aGimeno-Ruiz, Sofía
000161702 700__ $$aRey-García, Jimena
000161702 700__ $$aMorales-Suarez-Varela, María
000161702 700__ $$aGuallar-Castillón, Pilar
000161702 7102_ $$11011$$2615$$aUniversidad de Zaragoza$$bDpto. Microb.Ped.Radio.Sal.Pú.$$cÁrea Medic.Prevent.Salud Públ.
000161702 773__ $$g17, 11 (2025), 1869 [16 pp.]$$pNutrients$$tNutrients$$x2072-6643
000161702 8564_ $$s808164$$uhttps://zaguan.unizar.es/record/161702/files/texto_completo.pdf$$yVersión publicada
000161702 8564_ $$s2828483$$uhttps://zaguan.unizar.es/record/161702/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000161702 909CO $$ooai:zaguan.unizar.es:161702$$particulos$$pdriver
000161702 951__ $$a2025-10-17-14:15:08
000161702 980__ $$aARTICLE