000161758 001__ 161758
000161758 005__ 20251017144558.0
000161758 0247_ $$2doi$$a10.1007/s00702-025-02958-4
000161758 0248_ $$2sideral$$a144380
000161758 037__ $$aART-2025-144380
000161758 041__ $$aeng
000161758 100__ $$aRivas-Diaz, Pablo
000161758 245__ $$aPost-awakening cortisol and resilience: unravelling their impact on cognitive decline
000161758 260__ $$c2025
000161758 5060_ $$aAccess copy available to the general public$$fUnrestricted
000161758 5203_ $$aAge-associated cognitive decline is a growing social problem and a major concern for older adults, highlighting the need to identify modifiable factors to mitigate it. The basal functioning of the hypothalamic-pituitary-adrenal (HPA) axis, and, especially, the post-awakening cortisol levels, seems to play a key role in cognitive performance related to functions dependent on the prefrontal cortex and hippocampus. Regulating these cortisol levels is crucial in this context, and resilience has been recognized as vital for successful aging and cognitive functioning. This study was designed to examine how post-awakening cortisol levels (both the cortisol awakening response, CAR (AUCi) and total post-awakening cortisol secretion, AUCg) could predict cognitive decline across different domains, and explore the role of resilience in this relationship. To investigate this, a follow-up study conducted between 2018 (Wave 1, W1) and 2022 (Wave 2, W2) included 53 healthy adults who completed tasks assessing verbal fluency, executive function, declarative memory, and resilience in both waves to study the cognitive decline. Moreover, in W1, participants provided four morning saliva samples on two consecutive working days to assess post-awakening cortisol levels on days that were different from the cognitive testing sessions. Results showed a negative association between AUCg and both phonemic and semantic fluency decline, but not in other cognitive domains, indicating a beneficial effect of post-awakening cortisol secretion on cognitive maintenance that appears be domain specific. In addition, resilience positively mediated the association between the CAR and the maintenance of semantic fluency. These findings underscore the role of post-awakening cortisol levels in supporting resilience and protecting prefrontal cortex-dependent functions, such as semantic fluency, over functions reliant on the hippocampus.
000161758 536__ $$9info:eu-repo/grantAgreement/ES/AEI/RED2022-134191-T$$9info:eu-repo/grantAgreement/ES/DGA/S31-23R$$9info:eu-repo/grantAgreement/ES/MICINN/PID2020-119406GB-I00
000161758 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttps://creativecommons.org/licenses/by/4.0/deed.es
000161758 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000161758 700__ $$aTrillo-Figueroa, David
000161758 700__ $$aRodriguez-Hernandez, Valerie
000161758 700__ $$aSanMiguel, Noemi
000161758 700__ $$0(orcid)0000-0003-3920-1099$$aHidalgo, Vanesa$$uUniversidad de Zaragoza
000161758 700__ $$aSalvador, Alicia
000161758 7102_ $$14009$$2725$$aUniversidad de Zaragoza$$bDpto. Psicología y Sociología$$cÁrea Psicobiología
000161758 773__ $$g(2025), [12 pp.]$$pJ. neural transm.$$tJOURNAL OF NEURAL TRANSMISSION$$x0300-9564
000161758 8564_ $$s1123894$$uhttps://zaguan.unizar.es/record/161758/files/texto_completo.pdf$$yVersión publicada
000161758 8564_ $$s2477330$$uhttps://zaguan.unizar.es/record/161758/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000161758 909CO $$ooai:zaguan.unizar.es:161758$$particulos$$pdriver
000161758 951__ $$a2025-10-17-14:13:46
000161758 980__ $$aARTICLE