000161768 001__ 161768 000161768 005__ 20251107103407.0 000161768 0247_ $$2doi$$a10.1111/sms.70090 000161768 0248_ $$2sideral$$a144438 000161768 037__ $$aART-2025-144438 000161768 041__ $$aeng 000161768 100__ $$aSánchez-Valdepeñas, Juan 000161768 245__ $$aEffects of different velocity loss thresholds in full squat with and without blood flow restriction on strength gains, neuromuscular adaptations, and muscle hypertrophy 000161768 260__ $$c2025 000161768 5060_ $$aAccess copy available to the general public$$fUnrestricted 000161768 5203_ $$aABSTRACTThis study aimed to analyze the effects of four full‐squat (SQ) training programs that differed in the blood flow condition [free flow (FF) versus restricted (BFR)] and in the velocity loss (VL) induced within the set (20% vs. 40%) on strength gains and muscle hypertrophy. Fifty‐two strength‐trained men followed an 8‐week (16 sessions) SQ training program from 55% to 70% 1‐repetition maximum (1RM) (FF20: n = 14; BFR20: n = 13; FF40: n = 12; BFR40: n = 13). The number of sets n = 13 per session and the inter‐set recovery periods (2 min) were matched between groups. A 50% arterial occlusion pressure was applied and maintained during the inter‐set recovery for BFR groups. The following tests were carried out before and after the training intervention: (1) cross‐sectional area of the vastus lateralis (ACSA); (2) countermovement jump; (3) progressive loading SQ test; and (4) fatigue SQ test. No significant BFR × VL × time interactions were observed. For 1RM and strength‐derived outcomes from the progressive loading test, significant VL × time interactions (p = 0.01–0.05) in favor of 20% VL groups were found. Regarding jump performance, a significant VL × time interaction (p = 0.02) also favored the 20% VL groups. A BFR × time interaction (p = 0.02) was observed in favor of the BFR condition for ACSA. Prescribing a certain level of effort through VL results in similar jump and strength performance improvements, regardless of blood flow condition, with optimal gains achieved at a moderate VL threshold (20%). Additionally, the BFR condition maximized muscle hypertrophy compared to FF, making it a valuable strategy for muscle growth. 000161768 536__ $$9info:eu-repo/grantAgreement/ES/ISCIII/CB16-10-00477$$9info:eu-repo/grantAgreement/ES/MICINN/FPU19/00891$$9info:eu-repo/grantAgreement/ES/MICINN/PID2020-117915RA-I00 000161768 540__ $$9info:eu-repo/semantics/embargoedAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/ 000161768 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/acceptedVersion 000161768 700__ $$0(orcid)0000-0002-0541-2050$$aAsín-Izquierdo, Iván$$uUniversidad de Zaragoza 000161768 700__ $$0(orcid)0000-0002-2737-5270$$aCornejo-Daza, Pedro Jesús$$uUniversidad de Zaragoza 000161768 700__ $$aMariscal, Gonzalo 000161768 700__ $$aRomagnoli, Ruggero 000161768 700__ $$aAlcazar, Julian 000161768 700__ $$aGonzález-Badillo, Juan José 000161768 700__ $$aSaez de Villarreal, Eduardo 000161768 700__ $$aPareja-Blanco, Fernando 000161768 7102_ $$13001$$2187$$aUniversidad de Zaragoza$$bDpto. Expres.Music.Plást.Corp.$$cÁrea Didáctica Expres.Corporal 000161768 773__ $$g35, 6 (2025), e70090 [12 pp.]$$pScand. j. med. sci. sports$$tScandinavian Journal of Medicine and Science in Sports$$x0905-7188 000161768 8564_ $$s394210$$uhttps://zaguan.unizar.es/record/161768/files/texto_completo.pdf$$yPostprint$$zinfo:eu-repo/date/embargoEnd/2026-05-25 000161768 8564_ $$s1654254$$uhttps://zaguan.unizar.es/record/161768/files/texto_completo.jpg?subformat=icon$$xicon$$yPostprint$$zinfo:eu-repo/date/embargoEnd/2026-05-25 000161768 909CO $$ooai:zaguan.unizar.es:161768$$particulos$$pdriver 000161768 951__ $$a2025-11-07-10:32:20 000161768 980__ $$aARTICLE