000161873 001__ 161873
000161873 005__ 20251017144616.0
000161873 0247_ $$2doi$$a10.1002/btm2.70032
000161873 0248_ $$2sideral$$a144551
000161873 037__ $$aART-2025-144551
000161873 041__ $$aeng
000161873 100__ $$0(orcid)0000-0001-6786-2041$$aBayona, Clara
000161873 245__ $$aMicrofluidic approaches for liquid biopsy in glioblastoma: Insights into diagnostic and follow‐up strategies
000161873 260__ $$c2025
000161873 5060_ $$aAccess copy available to the general public$$fUnrestricted
000161873 5203_ $$aGlioblastoma (GBM) is a highly malignant brain tumor with a poor survival prognosis of 12–15 months despite current therapeutic strategies. Diagnosing GBM is challenging, often requiring invasive techniques such as tissue biopsy and imaging methods that can provide inconclusive results. In this regard, liquid biopsy represents a promising alternative, providing tumor‐derived information from less invasive sources such as blood or cerebrospinal fluid. However, the typically low concentrations of these biomarkers pose challenges for traditional detection techniques, limiting their sensitivity and specificity. Recent advances in microfluidics offer a potential solution by enhancing the isolation and detection of tumor‐derived cells and molecules, thus improving their detectability. This review discusses the latest progress in microfluidic‐based liquid biopsy systems for glioblastoma, laying the basis for future diagnostic practices that are less invasive and more accurate. As these technologies evolve, they hold the potential to transform GBM diagnosis and monitoring, ultimately improving patient outcomes.
000161873 536__ $$9info:eu-repo/grantAgreement/ES/AEI/PID2021-126051OB-C41$$9info:eu-repo/grantAgreement/ES/DGA/T62-230R$$9info:eu-repo/grantAgreement/ES/MINECO/DIN2020-011544
000161873 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttps://creativecommons.org/licenses/by/4.0/deed.es
000161873 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000161873 700__ $$0(orcid)0000-0001-7232-7588$$aRandelovic, Teodora
000161873 700__ $$aOlaizola-Rodrigo, Claudia
000161873 700__ $$0(orcid)0000-0003-2410-5678$$aOchoa, Ignacio$$uUniversidad de Zaragoza
000161873 7102_ $$11003$$2443$$aUniversidad de Zaragoza$$bDpto. Anatom.Histolog.Humanas$$cArea Histología
000161873 773__ $$g(2025), 16 pp.$$pBioeng. transl. med.$$tBioengineering & translational medicine$$x2380-6761
000161873 8564_ $$s13276507$$uhttps://zaguan.unizar.es/record/161873/files/texto_completo.pdf$$yVersión publicada
000161873 8564_ $$s2356578$$uhttps://zaguan.unizar.es/record/161873/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000161873 909CO $$ooai:zaguan.unizar.es:161873$$particulos$$pdriver
000161873 951__ $$a2025-10-17-14:19:30
000161873 980__ $$aARTICLE